ENZYME entry: EC 1.2.1.10

Accepted Name
Acetaldehyde dehydrogenase (acetylating).
Alternative Name(s)
Acylating acetaldehyde dehydrogenase.
Aldehyde dehydrogenase (acylating).
Reaction catalysed
Acetaldehyde + CoA + NAD(+) <=> acetyl-CoA + NADH
Comment(s)
  • Also acts, more slowly, on glycolaldehyde, propanal and butanal.
  • In several bacterial species this enzyme forms a bifunctional complex with EC 4.1.3.39.
  • The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.87.
  • Involved in the meta-cleavage pathway for the degradation of phenols, methylphenols and catechols.
  • NADP(+) can replace NAD(+) but the rate of reaction is much slower.
Cross-references
PROSITEPDOC00059
BRENDA1.2.1.10
EC2PDB1.2.1.10
ExplorEnz1.2.1.10
PRIAM enzyme-specific profiles1.2.1.10
KEGG Ligand Database for Enzyme Nomenclature1.2.1.10
IUBMB Enzyme Nomenclature1.2.1.10
IntEnz1.2.1.10
MEDLINEFind literature relating to 1.2.1.10
MetaCyc1.2.1.10
UniProtKB/Swiss-Prot
A1K6L8, ACDH1_AZOSB;  C1DMT1, ACDH1_AZOVD;  B4EK77, ACDH1_BURCJ;  
B2JLM7, ACDH1_BURP8;  Q397R0, ACDH1_BURS3;  A4JPX8, ACDH1_BURVG;  
Q143P8, ACDH1_BURXL;  Q83VZ4, ACDH1_COMTE;  Q0K3S6, ACDH1_CUPNH;  
Q47HL9, ACDH1_DECAR;  A8LAA2, ACDH1_FRASN;  A2SI34, ACDH1_METPP;  
B1MH39, ACDH1_MYCA9;  B2HGH0, ACDH1_MYCMM;  A0QZU1, ACDH1_MYCS2;  
A3Q4B8, ACDH1_MYCSJ;  A1UM81, ACDH1_MYCSK;  Q1B2X0, ACDH1_MYCSS;  
A0PR19, ACDH1_MYCUA;  Q5Z2N3, ACDH1_NOCFA;  A1SH78, ACDH1_NOCSJ;  
A4XF36, ACDH1_NOVAD;  A5W4E5, ACDH1_PSEP1;  Q4F8I0, ACDH1_PSEPS;  
B1J6Y6, ACDH1_PSEPW;  Q1LNS3, ACDH1_RALME;  C0ZPX0, ACDH1_RHOE4;  
C1B7L1, ACDH1_RHOOB;  Q0SJD4, ACDH1_RHOSR;  A8M1N1, ACDH1_SALAI;  
A5V6T7, ACDH1_SPHWW;  A1K6Y5, ACDH2_AZOSB;  C1DRI9, ACDH2_AZOVD;  
B4EFI8, ACDH2_BURCJ;  B2JQV9, ACDH2_BURP8;  Q396N9, ACDH2_BURS3;  
A4JW24, ACDH2_BURVG;  Q13VU2, ACDH2_BURXL;  Q9RHN2, ACDH2_COMTE;  
Q0K3N1, ACDH2_CUPNH;  Q47GC7, ACDH2_DECAR;  A8LEP9, ACDH2_FRASN;  
A2SL36, ACDH2_METPP;  B1MJT8, ACDH2_MYCA9;  B2HI26, ACDH2_MYCMM;  
A0R4S7, ACDH2_MYCS2;  A3Q6N0, ACDH2_MYCSJ;  A1UQA0, ACDH2_MYCSK;  
Q1B0P7, ACDH2_MYCSS;  A0PUX3, ACDH2_MYCUA;  A1TDB8, ACDH2_MYCVP;  
Q5YV94, ACDH2_NOCFA;  A1SIM4, ACDH2_NOCSJ;  A4XDT7, ACDH2_NOVAD;  
A5W4F9, ACDH2_PSEP1;  Q52039, ACDH2_PSEPS;  B1J6Y2, ACDH2_PSEPW;  
Q1LCQ9, ACDH2_RALME;  C0ZU49, ACDH2_RHOE4;  C1B8H9, ACDH2_RHOOB;  
Q0S9X0, ACDH2_RHOSR;  A8M6W7, ACDH2_SALAI;  C1DN56, ACDH3_AZOVD;  
Q390P5, ACDH3_BURS3;  Q13QH7, ACDH3_BURXL;  Q9S153, ACDH3_COMTE;  
Q47B12, ACDH3_DECAR;  A1TFQ6, ACDH3_MYCVP;  Q5YUH5, ACDH3_NOCFA;  
C1BAJ3, ACDH3_RHOOB;  Q0S816, ACDH3_RHOSR;  A5VGU5, ACDH3_SPHWW;  
C1DF11, ACDH4_AZOVD;  Q39LH7, ACDH4_BURS3;  Q79AF6, ACDH4_BURXL;  
Q479G9, ACDH4_DECAR;  C1AVG3, ACDH4_RHOOB;  Q0S4F9, ACDH4_RHOSR;  
Q479E6, ACDH5_DECAR;  C1AYB3, ACDH5_RHOOB;  Q0S005, ACDH5_RHOSR;  
C1BE29, ACDH6_RHOOB;  Q0RXC4, ACDH6_RHOSR;  Q0RWM7, ACDH7_RHOSR;  
A1W2K2, ACDH_ACISJ;  B9JML7, ACDH_AGRRK;  Q0A5T6, ACDH_ALKEH;  
A0RD69, ACDH_BACAH;  Q739I5, ACDH_BACC1;  C1ERL6, ACDH_BACC3;  
Q764S1, ACDH_BACPJ;  Q2KXU8, ACDH_BORA1;  C0ZDU5, ACDH_BREBN;  
Q2VLC6, ACDH_BURCE;  A3P826, ACDH_BURP0;  Q3JK54, ACDH_BURP1;  
A3NML3, ACDH_BURP6;  B2T2S1, ACDH_BURPP;  Q63JB0, ACDH_BURPS;  
Q2T7T0, ACDH_BURTA;  Q3ACM1, ACDH_CARHZ;  A9W9U2, ACDH_CHLAA;  
B8GBV4, ACDH_CHLAD;  B9LCM0, ACDH_CHLSY;  Q46NW7, ACDH_CUPPJ;  
B2AIJ6, ACDH_CUPTR;  B8G186, ACDH_DESHD;  A7ZI98, ACDH_ECO24;  
B7L507, ACDH_ECO55;  Q8X5J9, ACDH_ECO57;  B5Z2Q6, ACDH_ECO5E;  
B7NK04, ACDH_ECO7I;  B7MPB8, ACDH_ECO81;  B7M2Z9, ACDH_ECO8A;  
C4ZTB5, ACDH_ECOBW;  A7ZWZ8, ACDH_ECOHS;  B1J0S8, ACDH_ECOLC;  
P77580, ACDH_ECOLI;  B7N8Q8, ACDH_ECOLU;  B6HZX7, ACDH_ECOSE;  
B1LIN6, ACDH_ECOSM;  B0VXM6, ACDH_GEOSE;  A4IT43, ACDH_GEOTN;  
B5XQJ3, ACDH_KLEP3;  A6TAC5, ACDH_KLEP7;  B1Y2E6, ACDH_LEPCP;  
A6W1X2, ACDH_MARMS;  B8ESV1, ACDH_METSB;  Q2RHL2, ACDH_MOOTA;  
A0QAG8, ACDH_MYCA1;  Q7TTR4, ACDH_MYCBO;  A1KPM0, ACDH_MYCBP;  
C1AHZ3, ACDH_MYCBT;  A4T7U3, ACDH_MYCGI;  Q743Q9, ACDH_MYCPA;  
A5U8K9, ACDH_MYCTA;  P9WQH2, ACDH_MYCTO;  P9WQH3, ACDH_MYCTU;  
Q6D797, ACDH_PECAS;  A5D522, ACDH_PELTS;  A1VUV2, ACDH_POLNA;  
Q120P0, ACDH_POLSJ;  Q3IEN6, ACDH_PSEHT;  Q49KG0, ACDH_PSEPU;  
Q9KWS1, ACDH_PSESP;  Q9ZI57, ACDH_PSEST;  Q52060, ACDH_PSEUF;  
B2UJF2, ACDH_RALPJ;  Q8XRG0, ACDH_RALSO;  Q221U6, ACDH_RHOFT;  
A7NLU3, ACDH_ROSCS;  A5UWE5, ACDH_ROSS1;  A4XAK8, ACDH_SALTO;  
B0TTT0, ACDH_SHEHH;  A8H4F0, ACDH_SHEPA;  B1KJL0, ACDH_SHEWM;  
Q3Z555, ACDH_SHISS;  O85978, ACDH_SPHAR;  A2TC44, ACDH_SPHYA;  
Q0PHY0, ACDH_SPIAU;  B1VRH6, ACDH_STRGG;  B9L2J1, ACDH_THERP;  
Q53WH9, ACDH_THET8;  A1WLL3, ACDH_VEREI;  A7IDU5, ACDH_XANP2;  
Q24803, ADH2_ENTHI;  P33744, ADHE_CLOAB;  P0A9Q8, ADHE_ECO57;  
P0A9Q7, ADHE_ECOLI;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
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