ENZYME entry: EC 1.2.1.71

Accepted Name
Succinylglutamate-semialdehyde dehydrogenase.
Alternative Name(s)
N-succinylglutamate 5-semialdehyde dehydrogenase.
SGSD.
Succinylglutamic semialdehyde dehydrogenase.
Reaction catalysed
N-succinyl-L-glutamate 5-semialdehyde + NAD(+) + H(2)O <=> N-succinyl-L-glutamate + NADH
Comment(s)
  • This is the fourth enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine.
  • This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA.
  • The five enzymes involved in this pathway are EC 2.3.1.109, EC 3.5.3.23, EC 2.6.1.11, EC 1.2.1.71 and EC 3.5.1.96.
Cross-references
PROSITEPDOC00068
BRENDA1.2.1.71
EC2PDB1.2.1.71
ExplorEnz1.2.1.71
PRIAM enzyme-specific profiles1.2.1.71
KEGG Ligand Database for Enzyme Nomenclature1.2.1.71
IUBMB Enzyme Nomenclature1.2.1.71
IntEnz1.2.1.71
MEDLINEFind literature relating to 1.2.1.71
MetaCyc1.2.1.71
UniProtKB/Swiss-Prot
Q9AAL5, ASTD1_CAUCR;  Q3IFT7, ASTD1_PSEHT;  Q12QD2, ASTD1_SHEDO;  
Q9A7W2, ASTD2_CAUCR;  Q3IC91, ASTD2_PSEHT;  Q12JA9, ASTD2_SHEDO;  
Q6FCQ0, ASTD_ACIAD;  A0KN18, ASTD_AERHH;  A4SK35, ASTD_AERS4;  
B6EML5, ASTD_ALISL;  B1YW19, ASTD_BURA4;  Q1BXP1, ASTD_BURCA;  
B1JYT5, ASTD_BURCC;  A0K608, ASTD_BURCH;  B4ECZ8, ASTD_BURCJ;  
Q0BGV0, ASTD_BURCM;  Q39I25, ASTD_BURL3;  A9AD19, ASTD_BURM1;  
Q62LN5, ASTD_BURMA;  A1V675, ASTD_BURMS;  A3NXG2, ASTD_BURP0;  
Q3JQC6, ASTD_BURP1;  A3NBM7, ASTD_BURP6;  Q63SD7, ASTD_BURPS;  
Q2SXN9, ASTD_BURTA;  A4JCW0, ASTD_BURVG;  Q141D3, ASTD_BURXL;  
B0T8I8, ASTD_CAUSK;  Q1QTQ7, ASTD_CHRSD;  Q7NXX7, ASTD_CHRVO;  
A8AHD8, ASTD_CITK8;  Q488Y0, ASTD_COLP3;  A7MNV8, ASTD_CROS8;  
A7ZML4, ASTD_ECO24;  B7USC7, ASTD_ECO27;  B7MAV7, ASTD_ECO45;  
B7L6M0, ASTD_ECO55;  Q7ADE6, ASTD_ECO57;  B5YQ33, ASTD_ECO5E;  
B7NT31, ASTD_ECO7I;  B7MVM5, ASTD_ECO81;  B7M1F8, ASTD_ECO8A;  
C4ZZA2, ASTD_ECOBW;  B1XGK7, ASTD_ECODH;  A8A0T8, ASTD_ECOHS;  
Q0TH84, ASTD_ECOL5;  Q8FH01, ASTD_ECOL6;  B1IPI4, ASTD_ECOLC;  
P76217, ASTD_ECOLI;  B7N582, ASTD_ECOLU;  B6IBG6, ASTD_ECOSE;  
B1LDY5, ASTD_ECOSM;  Q1RB47, ASTD_ECOUT;  A4W9J7, ASTD_ENT38;  
B2VJX8, ASTD_ERWT9;  B7LQ46, ASTD_ESCF3;  Q2SKP1, ASTD_HAHCH;  
Q5QVX3, ASTD_IDILO;  A6T7T5, ASTD_KLEP7;  Q5X4K4, ASTD_LEGPA;  
A5ICK3, ASTD_LEGPC;  Q5ZUT5, ASTD_LEGPH;  Q5WVZ4, ASTD_LEGPL;  
A1U5W8, ASTD_MARHV;  Q2G9T9, ASTD_NOVAD;  Q7N2G9, ASTD_PHOLL;  
Q6LVE5, ASTD_PHOPR;  Q48G19, ASTD_PSE14;  Q15Y60, ASTD_PSEA6;  
O50174, ASTD_PSEAE;  Q1I6Z5, ASTD_PSEE4;  Q4K837, ASTD_PSEF5;  
C3JXY7, ASTD_PSEFS;  A4XWE7, ASTD_PSEMY;  A5W0D5, ASTD_PSEP1;  
Q3K885, ASTD_PSEPF;  B0KR47, ASTD_PSEPG;  Q88EI4, ASTD_PSEPK;  
B1JCH3, ASTD_PSEPW;  Q885J7, ASTD_PSESM;  Q4ZQH8, ASTD_PSEU2;  
B5F7J0, ASTD_SALA4;  A9MFG0, ASTD_SALAR;  B5FJD6, ASTD_SALDC;  
B5QWI8, ASTD_SALEP;  B5RAZ9, ASTD_SALG2;  B4TGE2, ASTD_SALHS;  
B4T3Z6, ASTD_SALNS;  Q5PHC0, ASTD_SALPA;  A9N276, ASTD_SALPB;  
C0Q6X8, ASTD_SALPC;  B5BA70, ASTD_SALPK;  B4TUC3, ASTD_SALSV;  
Q8Z6G1, ASTD_SALTI;  Q8ZPV0, ASTD_SALTY;  A8GFQ3, ASTD_SERP5;  
B8EBC2, ASTD_SHEB2;  A3D039, ASTD_SHEB5;  A6WST7, ASTD_SHEB8;  
A9L3U4, ASTD_SHEB9;  Q07XY1, ASTD_SHEFN;  B0TU38, ASTD_SHEHH;  
Q8EJ54, ASTD_SHEON;  A8H8E0, ASTD_SHEPA;  A4Y344, ASTD_SHEPC;  
B8CIT6, ASTD_SHEPW;  A0KST2, ASTD_SHESA;  A8FRE9, ASTD_SHESH;  
A1RNU4, ASTD_SHESW;  B1KDF2, ASTD_SHEWM;  B2U3C8, ASTD_SHIB3;  
Q321N8, ASTD_SHIBS;  Q32G88, ASTD_SHIDS;  Q0T4V3, ASTD_SHIF8;  
Q7UCI7, ASTD_SHIFL;  A9EN94, ASTD_SORC5;  Q1GV29, ASTD_SPHAL;  
A5F529, ASTD_VIBC3;  A7MX96, ASTD_VIBCB;  Q9KNW4, ASTD_VIBCH;  
C3LRS7, ASTD_VIBCM;  Q5E2G9, ASTD_VIBF1;  B5FBM2, ASTD_VIBFM;  
Q87L22, ASTD_VIBPA;  B7VLI4, ASTD_VIBTL;  Q8DCS9, ASTD_VIBVU;  
Q7MH21, ASTD_VIBVY;  Q1C8A9, ASTD_YERPA;  B2K296, ASTD_YERPB;  
Q9ZC68, ASTD_YERPE;  A9QZ61, ASTD_YERPG;  A4TJU5, ASTD_YERPP;  
Q66B19, ASTD_YERPS;  B1JMD1, ASTD_YERPY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
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