ENZYME entry: EC 1.2.7.1

Accepted Name
Pyruvate synthase.
Alternative Name(s)
2-oxobutyrate synthase.
2-oxobutyrate-ferredoxin oxidoreductase.
Alpha-ketobutyrate synthase.
Alpha-ketobutyrate-ferredoxin oxidoreductase.
Pyruvate oxidoreductase.
Pyruvate synthetase.
Pyruvic-ferredoxin oxidoreductase.
Reaction catalysed
Pyruvate + CoA + 2 oxidized ferredoxin <=> acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+)
Cofactor(s)
Iron-sulfur; Thiamine diphosphate.
Comment(s)
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
Cross-references
BRENDA1.2.7.1
EC2PDB1.2.7.1
ExplorEnz1.2.7.1
PRIAM enzyme-specific profiles1.2.7.1
KEGG Ligand Database for Enzyme Nomenclature1.2.7.1
IUBMB Enzyme Nomenclature1.2.7.1
IntEnz1.2.7.1
MEDLINEFind literature relating to 1.2.7.1
MetaCyc1.2.7.1
UniProtKB/Swiss-Prot
P80521, PORA_METBF;  Q57715, PORA_METJA;  P56810, PORA_METTH;  
P80900, PORA_METTM;  Q9UYZ4, PORA_PYRAB;  Q51804, PORA_PYRFU;  
O73986, PORA_PYRHO;  O05651, PORA_THEMA;  P80522, PORB_METBF;  
Q57714, PORB_METJA;  O27771, PORB_METTH;  P80901, PORB_METTM;  
Q9UYZ5, PORB_PYRAB;  Q51805, PORB_PYRFU;  O58417, PORB_PYRHO;  
Q56317, PORB_THEMA;  P80523, PORC_METBF;  Q57717, PORC_METJA;  
O27772, PORC_METTH;  P80902, PORC_METTM;  Q9UYY9, PORC_PYRAB;  
P84819, PORC_PYREN;  Q51799, PORC_PYRFU;  O58411, PORC_PYRHO;  
Q5JIK2, PORC_THEKO;  P84820, PORC_THELN;  O05650, PORC_THEMA;  
P94692, POR_DESAF;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
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