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ENZYME entry: EC 1.2.7.7

Accepted Name
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
Alternative Name(s)
2-ketoisovalerate ferredoxin reductase.
2-oxoisovalerate ferredoxin reductase.
3-methyl-2-oxobutanoate synthase (ferredoxin).
Branched-chain ketoacid ferredoxin reductase.
Branched-chain oxo acid ferredoxin reductase.
Keto-valine-ferredoxin oxidoreductase.
Ketoisovalerate ferredoxin reductase.
Ketoisovalerate oxidoreductase.
VOR.
Reaction catalysed
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin <=> S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+)
Cofactor(s)
Iron-sulfur; Tungstopterin.
Comment(s)
  • Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- pentanoate, 2-oxobutyrate and 3-methylthiopropanamine.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.3.
Cross-references
BRENDA1.2.7.7
EC2PDB1.2.7.7
ExplorEnz1.2.7.7
PRIAM enzyme-specific profiles1.2.7.7
KEGG Ligand Database for Enzyme Nomenclature1.2.7.7
IUBMB Enzyme Nomenclature1.2.7.7
IntEnz1.2.7.7
MEDLINEFind literature relating to 1.2.7.7
MetaCyc1.2.7.7
UniProtKB/Swiss-Prot
B6D9A7, BEA2_BEABA;  S0EGG0, BEA2_GIBF5;  G3GBU6, BEA2_GIBIN;  
Q9UYY9, PORC_PYRAB;  P84819, PORC_PYREN;  Q51799, PORC_PYRFU;  
O58411, PORC_PYRHO;  Q5JIK2, PORC_THEKO;  P84820, PORC_THELN;  
O26801, VORA_METTH;  Q9UYZ1, VORA_PYRAB;  Q51801, VORA_PYRFU;  
O58413, VORA_PYRHO;  O26800, VORB_METTH;  P80908, VORB_METTM;  
Q9UYZ2, VORB_PYRAB;  Q51802, VORB_PYRFU;  O58414, VORB_PYRHO;  
O26799, VORC_METTH;  P80909, VORC_METTM;  Q9UYZ0, VORD_PYRAB;  
Q51800, VORD_PYRFU;  O58412, VORD_PYRHO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
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