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ENZYME

ENZYME entry: EC 1.3.1.14

Accepted Name
dihydroorotate dehydrogenase (NAD(+))
Alternative Name(s)
DHOD
DHODase
DHOdehase
dihydroorotate oxidase
orotate reductase (NADH)
orotate reductase (NADH2)
Reaction catalysed
(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate
Comment(s)
  • The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
Cross-references
BRENDA1.3.1.14
EC2PDB1.3.1.14
ExplorEnz1.3.1.14
PRIAM enzyme-specific profiles1.3.1.14
KEGG Ligand Database for Enzyme Nomenclature1.3.1.14
IUBMB Enzyme Nomenclature1.3.1.14
IntEnz1.3.1.14
MEDLINEFind literature relating to 1.3.1.14
MetaCyc1.3.1.14
Rhea expert-curated reactions1.3.1.14
UniProtKB/Swiss-Prot
A6TVS0, PYRDB_ALKMQA8MIU4, PYRDB_ALKOOB7GFA1, PYRDB_ANOFW
O29513, PYRDB_ARCFUB6YRL9, PYRDB_AZOPCC3P654, PYRDB_BACAA
C3L742, PYRDB_BACACA0RHQ6, PYRDB_BACAHQ81WF4, PYRDB_BACAN
B7JJX1, PYRDB_BACC0Q732I5, PYRDB_BACC1B7IUP4, PYRDB_BACC2
C1EPP8, PYRDB_BACC3B7H6M0, PYRDB_BACC4B7HLL8, PYRDB_BACC7
P46539, PYRDB_BACCLA7GRK9, PYRDB_BACCNB9IVW1, PYRDB_BACCQ
Q819S5, PYRDB_BACCRQ636E2, PYRDB_BACCZQ5LCI2, PYRDB_BACFN
Q64TN0, PYRDB_BACFRQ6HET0, PYRDB_BACHKA9VTC4, PYRDB_BACMK
A8FD19, PYRDB_BACP2P25996, PYRDB_BACSUQ8A9C3, PYRDB_BACTN
A7Z4H4, PYRDB_BACVZC0QYH6, PYRDB_BRAHWB9MS26, PYRDB_CALBD
Q8R9R7, PYRDB_CALS4A4XKT6, PYRDB_CALS8Q3AC05, PYRDB_CARHZ
B5EFU4, PYRDB_CITBBQ18CS6, PYRDB_CLOD6Q6A912, PYRDB_CUTAK
B1I4M6, PYRDB_DESAPA4J560, PYRDB_DESRMB1GYY3, PYRDB_ENDTX
P0DH74, PYRDB_ENTFAF2MMN9, PYRDB_ENTFOB1YIR7, PYRDB_EXIS2
Q8RG85, PYRDB_FUSNNB9M211, PYRDB_GEODFQ5L0U1, PYRDB_GEOKA
Q39UK4, PYRDB_GEOMGQ74CB9, PYRDB_GEOSLC6E6N2, PYRDB_GEOSM
C5D8Q2, PYRDB_GEOSWA4IM35, PYRDB_GEOTNA5G3H0, PYRDB_GEOUR
Q9K9W1, PYRDB_HALH5B0TGQ8, PYRDB_HELMIQ9CFW8, PYRDB_LACLA
P54322, PYRDB_LACLMA9KKR5, PYRDB_LACP7Q38X22, PYRDB_LATSS
Q92AH5, PYRDB_LISINC1KWD2, PYRDB_LISMCQ71YI3, PYRDB_LISMF
B8DDR9, PYRDB_LISMHQ8Y667, PYRDB_LISMOA0AJT8, PYRDB_LISW6
Q8EUY2, PYRDB_MALP2C6BW12, PYRDB_MARSDQ8TT55, PYRDB_METAC
Q0W8E1, PYRDB_METARQ58070, PYRDB_METJAQ8TXU6, PYRDB_METKA
Q8PW56, PYRDB_METMAO27281, PYRDB_METTHB2A2U4, PYRDB_NATTJ
Q8CWG1, PYRDB_OCEIHA6LB11, PYRDB_PARD8A1ASB3, PYRDB_PELPD
A9BJH4, PYRDB_PETMOA6L5H1, PYRDB_PHOV8Q7MVJ6, PYRDB_PORGI
Q9V0Y6, PYRDB_PYRABQ8U0P6, PYRDB_PYRFUO59185, PYRDB_PYRHO
Q9UX04, PYRDB_SACS2Q5WFJ4, PYRDB_SHOC1C4XPD6, PYRDB_SOLM1
B9DPN4, PYRDB_STACTQ97R65, PYRDB_STRPNQ8DQ37, PYRDB_STRR6
O08358, PYRDB_SULACQ0AXG6, PYRDB_SYNWWQ9HL35, PYRDB_THEAC
Q5JHR7, PYRDB_THEKOQ9WYG8, PYRDB_THEMAA5IK84, PYRDB_THEP1
B0KA32, PYRDB_THEP3B0K2E5, PYRDB_THEPXQ979G6, PYRDB_THEVO
B5YJH1, PYRDB_THEYDB3E4T4, PYRDB_TRIL1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
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