ENZYME entry: EC 1.3.98.1

Accepted Name
Dihydroorotate oxidase (fumarate).
Alternative Name(s)
DHOD.
DHODase.
DHOdehase.
Dihydoorotic acid dehydrogenase.
Dihydroorotate dehydrogenase.
Dihydroorotate oxidase.
Reaction catalysed
(S)-dihydroorotate + fumarate <=> orotate + succinate
Cofactor(s)
FMN.
Comment(s)
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides.
  • Molecular oxygen can replace fumarate in vitro.
  • Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
  • Formerly EC 1.3.3.1.
Cross-references
PROSITEPDOC00708
BRENDA1.3.98.1
EC2PDB1.3.98.1
ExplorEnz1.3.98.1
PRIAM enzyme-specific profiles1.3.98.1
KEGG Ligand Database for Enzyme Nomenclature1.3.98.1
IUBMB Enzyme Nomenclature1.3.98.1
IntEnz1.3.98.1
MEDLINEFind literature relating to 1.3.98.1
MetaCyc1.3.98.1
UniProtKB/Swiss-Prot
Q7Z895, PYRD1_KLULA;  Q7Z892, PYRD1_LACK1;  Q9YFI6, PYRDA_AERPE;  
O66461, PYRDA_AQUAE;  P59626, PYRDA_ENTFA;  Q5FJB5, PYRDA_LACAC;  
Q038Z3, PYRDA_LACC3;  Q1G864, PYRDA_LACDA;  Q047M3, PYRDA_LACDB;  
A8YVZ9, PYRDA_LACH4;  Q74J29, PYRDA_LACJO;  Q9CFC9, PYRDA_LACLA;  
Q53ZE5, PYRDA_LACLC;  A2RJT9, PYRDA_LACLM;  P77887, PYRDA_LACPL;  
A5VHS3, PYRDA_LACRD;  B2G5A3, PYRDA_LACRJ;  Q03HA9, PYRDA_PEDPA;  
Q01YA2, PYRDA_SOLUE;  Q3K2G4, PYRDA_STRA1;  Q8E6L0, PYRDA_STRA3;  
Q8E155, PYRDA_STRA5;  C0M8R7, PYRDA_STRE4;  Q99Z28, PYRDA_STRP1;  
P0DD66, PYRDA_STRP3;  Q8P0C0, PYRDA_STRP8;  A2RDV3, PYRDA_STRPG;  
Q9X9S0, PYRDA_STRPN;  P0DD67, PYRDA_STRPQ;  Q8DQG9, PYRDA_STRR6;  
C0MCW6, PYRDA_STRS7;  B9DUS7, PYRDA_STRU0;  B2V726, PYRDA_SULSY;  
Q6V3X0, PYRD_NAUCC;  Q7Z894, PYRD_SACBA;  Q7Z893, PYRD_SACMI;  
Q7Z891, PYRD_SACPA;  Q57U83, PYRD_TRYB2;  Q4D3W2, PYRD_TRYCC;  
P28272, PYRD_YEAST;  

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