ENZYME

ENZYME entry: EC 1.3.8.9

Accepted Name

Very-long-chain acyl-CoA dehydrogenase.

Reaction catalysed

A very-long-chain acyl-CoA + electron-transfer flavoprotein <=> a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein

Cofactor(s)

FAD.

Comment(s)

One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
The enzyme is most active toward long-chain acyl-CoAs such as C(14), C(16) and C(18), but is also active with very-long-chain acyl-CoAs up to 24 carbons.
It shows no activity for substrates of less than 12 carbons.
It's specific activity toward palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase.
cf. EC 1.3.8.1, EC 1.3.8.7 and EC 1.3.8.8.
Formerly EC 1.3.99.3.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature