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ENZYME entry: EC 1.8.98.1

Accepted Name
CoB--CoM heterodisulfide reductase.
Alternative Name(s)
Heterodisulfide reductase.
Soluble heterodisulfide reductase.
Reaction catalysed
Coenzyme B + coenzyme M + methanophenazine <=> N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine
Cofactor(s)
Heme; Iron-sulfur.
Comment(s)
  • Found in methanogenic archaea, particularly Methanosarcina species, and regenerates coenzyme M and coenzyme B after the action of EC 2.8.4.1.
  • Highly specific for both coenzyme M and coenzyme B.
  • Reacts with various phenazine derivatives, including 2-hydroxyphenazine and 2-bromophenazine.
  • Formerly EC 1.12.99.2.
Cross-references
BRENDA1.8.98.1
EC2PDB1.8.98.1
ExplorEnz1.8.98.1
PRIAM enzyme-specific profiles1.8.98.1
KEGG Ligand Database for Enzyme Nomenclature1.8.98.1
IUBMB Enzyme Nomenclature1.8.98.1
IntEnz1.8.98.1
MEDLINEFind literature relating to 1.8.98.1
MetaCyc1.8.98.1
UniProtKB/Swiss-Prot
Q8TYP4, HDRA1_METKA;  P96801, HDRA2_METKA;  Q8TM02, HDRA_METAC;  
P60200, HDRA_METJA;  Q8Q0T0, HDRA_METMA;  Q6LWL2, HDRA_METMP;  
O27434, HDRA_METTH;  Q50756, HDRA_METTM;  Q58153, HDRB1_METJA;  
Q58273, HDRB2_METJA;  Q8TIB8, HDRB_METAC;  Q8TXT8, HDRB_METKA;  
Q8PY83, HDRB_METMA;  O27907, HDRB_METTH;  Q50755, HDRB_METTM;  
Q58154, HDRC1_METJA;  Q58274, HDRC2_METJA;  Q8TIB9, HDRC_METAC;  
Q8TXT7, HDRC_METKA;  Q8PY84, HDRC_METMA;  O27906, HDRC_METTH;  
Q50754, HDRC_METTM;  Q8TSV7, HDRD_METAC;  P96797, HDRD_METBF;  
Q8PVW3, HDRD_METMA;  Q8TSV8, HDRE_METAC;  P96796, HDRE_METBF;  
Q8PVW4, HDRE_METMA;  

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