ENZYME entry: EC

Accepted Name
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase.
Alternative Name(s)
(RS)-tetrahydrobenzylisoquinoline N-methyltransferase.
Norreticuline N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline <=> S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
  • Broad substrate specificity for (RS)-1-benzyl-1,2,3,4- tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine.
  • Both R- and S-enantiomers are methylated.
  • Participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants.
  • The physiological substrate is likely to be coclaurine.
  • Was earlier termed norreticuline N-methyltransferase.
  • However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1- benzyl-1,2,3,4-tetrahydroisoquinolines.
PRIAM enzyme-specific profiles2.1.1.115
KEGG Ligand Database for Enzyme Nomenclature2.1.1.115
IUBMB Enzyme Nomenclature2.1.1.115
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