Due to maintenance work, this service will not be available from Monday June 27th 5.00 pm until Monday June 27th 9.00 pm CEST.

ENZYME entry: EC 2.1.1.115

Accepted Name
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase.
Alternative Name(s)
(RS)-tetrahydrobenzylisoquinoline N-methyltransferase.
Norreticuline N-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline <=> S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline
Comment(s)
  • Broad substrate specificity for (RS)-1-benzyl-1,2,3,4- tetrahydroisoquinolines; including coclaurine, norcoclaurine, isococlaurine, norarmepavine, norreticuline and tetrahydropapaverine.
  • Both R- and S-enantiomers are methylated.
  • Participates in the pathway leading to benzylisoquinoline alkaloid synthesis in plants.
  • The physiological substrate is likely to be coclaurine.
  • Was earlier termed norreticuline N-methyltransferase.
  • However, norreticuline has not been found to occur in nature and that name does not reflect the broad specificity of the enzyme for (RS)-1- benzyl-1,2,3,4-tetrahydroisoquinolines.
Cross-references
BRENDA2.1.1.115
EC2PDB2.1.1.115
ExplorEnz2.1.1.115
PRIAM enzyme-specific profiles2.1.1.115
KEGG Ligand Database for Enzyme Nomenclature2.1.1.115
IUBMB Enzyme Nomenclature2.1.1.115
IntEnz2.1.1.115
MEDLINEFind literature relating to 2.1.1.115
MetaCyc2.1.1.115

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-