Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC

Accepted Name
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase.
Reaction catalysed
  • S-adenosyl-L-methionine + cytosine(34) in tRNA precursor <=> S-adenosyl-L-homocysteine + 5-methylcytosine(34) in tRNA precursor
  • S-adenosyl-L-methionine + cytosine(40) in tRNA precursor <=> S-adenosyl-L-homocysteine + 5-methylcytosine(40) in tRNA precursor
  • S-adenosyl-L-methionine + cytosine(48) in tRNA <=> S-adenosyl-L-homocysteine + 5-methylcytosine(48) in tRNA
  • S-adenosyl-L-methionine + cytosine(49) in tRNA <=> S-adenosyl-L-homocysteine + 5-methylcytosine(49) in tRNA
  • The enzyme from Saccharomyces cerevisiae is responsible for complete 5-methylcytosine methylations of yeast tRNA.
  • The incidence of modification depends on the cytosine position in tRNA.
  • At positions 34 and 40, 5-methylcytosine is found only in two yeast tRNAs (tRNA(Leu)(CUA) and tRNA(Phe)(GAA), respectively), whereas most other elongator yeast tRNAs bear either 5-methylcytosine(48) or 5-methylcytosine(49), but never both in the same tRNA molecule.
  • The formation of 5-methylcytosine(34) and 5-methylcytosine(40) is a strictly intron-dependent process, whereas the formation of 5-methylcytosine(48) and 5-methylcytosine(49) is an intron- independent process.
  • Formerly EC
PRIAM enzyme-specific profiles2.1.1.202
KEGG Ligand Database for Enzyme Nomenclature2.1.1.202
IUBMB Enzyme Nomenclature2.1.1.202
MEDLINEFind literature relating to
P38205, NCL1_YEAST

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-