ENZYME entry: EC 2.1.1.222

Accepted Name
2-polyprenyl-6-hydroxyphenol methylase.
Alternative Name(s)
2-octaprenyl-6-hydroxyphenol methylase.
Reaction catalysed
S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol <=> S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol
Comment(s)
  • UbiG catalyzes both methylation steps in ubiquinone biosynthesis in Escherichia coli.
  • The second methylation is classified as EC 2.1.1.64.
  • In eukaryotes Coq3 catalyzes the two methylation steps in ubiquinone biosynthesis.
  • However, while the second methylation is common to both enzymes, the first methylation by Coq3 occurs at a different position within the pathway, and thus involves a different substrate and is classified as EC 2.1.1.114.
  • The substrate of the eukaryotic enzyme (3,4-dihydroxy-5-all-trans- polyprenylbenzoate) differs by an additional carboxylate moiety.
Cross-references
BRENDA2.1.1.222
EC2PDB2.1.1.222
ExplorEnz2.1.1.222
PRIAM enzyme-specific profiles2.1.1.222
KEGG Ligand Database for Enzyme Nomenclature2.1.1.222
IUBMB Enzyme Nomenclature2.1.1.222
IntEnz2.1.1.222
MEDLINEFind literature relating to 2.1.1.222
MetaCyc2.1.1.222
UniProtKB/Swiss-Prot
O49354, COQ3_ARATH;  Q3T131, COQ3_BOVIN;  O93995, COQ3_CANAX;  
Q54XD0, COQ3_DICDI;  Q9NZJ6, COQ3_HUMAN;  Q8BMS4, COQ3_MOUSE;  
Q63159, COQ3_RAT;  O74421, COQ3_SCHPO;  P27680, COQ3_YEAST;  
A1TSA0, UBIG_ACIAC;  Q6FFY1, UBIG_ACIAD;  B7H2Y9, UBIG_ACIB3;  
B7IBN2, UBIG_ACIB5;  B2I023, UBIG_ACIBC;  B0VMN8, UBIG_ACIBS;  
B0V5X4, UBIG_ACIBY;  A3MZ07, UBIG_ACTP2;  B3H0C8, UBIG_ACTP7;  
A4SM99, UBIG_AERS4;  B9JB78, UBIG_AGRRK;  Q8UA66, UBIG_AGRT5;  
Q0AA73, UBIG_ALKEH;  Q5P7U3, UBIG_AROAE;  A8HVC4, UBIG_AZOC5;  
A1K8Q1, UBIG_AZOSB;  C1DRQ3, UBIG_AZOVD;  A1URT5, UBIG_BARBK;  
Q6G5K3, UBIG_BARHE;  Q6G0I1, UBIG_BARQU;  A9IQF4, UBIG_BART1;  
Q2L2T5, UBIG_BORA1;  Q7WGT9, UBIG_BORBR;  Q7W5Z6, UBIG_BORPA;  
Q7VZG7, UBIG_BORPE;  Q89XU2, UBIG_BRADU;  A4YKT6, UBIG_BRASO;  
B2S828, UBIG_BRUA1;  Q2YLN5, UBIG_BRUA2;  A9M8K8, UBIG_BRUC2;  
C0RFB8, UBIG_BRUMB;  Q8YJ98, UBIG_BRUME;  A5VSK3, UBIG_BRUO2;  
B0CIC6, UBIG_BRUSI;  Q8FYK0, UBIG_BRUSU;  B1YV26, UBIG_BURA4;  
Q1BY35, UBIG_BURCA;  B1JXR2, UBIG_BURCC;  A0K5L4, UBIG_BURCH;  
B4EB49, UBIG_BURCJ;  Q0BHA0, UBIG_BURCM;  Q39IG8, UBIG_BURL3;  
A9ADW3, UBIG_BURM1;  Q62M18, UBIG_BURMA;  Q3JPX1, UBIG_BURP1;  
B2JEZ6, UBIG_BURP8;  B2T641, UBIG_BURPP;  Q63RZ8, UBIG_BURPS;  
Q2SY32, UBIG_BURTA;  A4JCG7, UBIG_BURVG;  Q13VB4, UBIG_BURXL;  
B8H209, UBIG_CAUCN;  Q9A9X1, UBIG_CAUCR;  B0SW81, UBIG_CAUSK;  
Q11E01, UBIG_CHESB;  Q7NZ91, UBIG_CHRVO;  A8ADY5, UBIG_CITK8;  
Q482G8, UBIG_COLP3;  B6J5Y2, UBIG_COXB1;  B6J1W2, UBIG_COXB2;  
A9KGL7, UBIG_COXBN;  A9NBI0, UBIG_COXBR;  Q820B5, UBIG_COXBU;  
A7MPA9, UBIG_CROS8;  Q46Y42, UBIG_CUPPJ;  Q47GP8, UBIG_DECAR;  
A8LQ43, UBIG_DINSH;  A7ZP50, UBIG_ECO24;  B7UFP4, UBIG_ECO27;  
B7MFZ8, UBIG_ECO45;  B7LAP9, UBIG_ECO55;  Q8XE29, UBIG_ECO57;  
B5YX17, UBIG_ECO5E;  B7NN47, UBIG_ECO7I;  B7MXR3, UBIG_ECO81;  
B7M5R7, UBIG_ECO8A;  C4ZU73, UBIG_ECOBW;  B1X8C6, UBIG_ECODH;  
A8A296, UBIG_ECOHS;  Q0TFL0, UBIG_ECOL5;  Q8FFP0, UBIG_ECOL6;  
B1IXV6, UBIG_ECOLC;  P17993, UBIG_ECOLI;  B7N5J4, UBIG_ECOLU;  
B6I7I7, UBIG_ECOSE;  B1LLI3, UBIG_ECOSM;  Q1R9I4, UBIG_ECOUT;  
A4WCN5, UBIG_ENT38;  B2VIL6, UBIG_ERWT9;  B7LM95, UBIG_ESCF3;  
Q7VKW2, UBIG_HAEDU;  B8F4B1, UBIG_HAEPS;  Q2SE61, UBIG_HAHCH;  
Q0I3Y4, UBIG_HISS1;  B0UUV6, UBIG_HISS2;  Q5QZ53, UBIG_IDILO;  
Q28VP7, UBIG_JANSC;  B5XNZ3, UBIG_KLEP3;  A6TBT7, UBIG_KLEP7;  
B1Y2L3, UBIG_LEPCP;  Q2W6W0, UBIG_MAGSA;  A1U3K1, UBIG_MARHV;  
Q0AME1, UBIG_MARMM;  Q609G2, UBIG_METCA;  B8IUB0, UBIG_METNO;  
B0UAV0, UBIG_METS4;  B8EI29, UBIG_METSB;  A9M0C4, UBIG_NEIM0;  
Q9JWE6, UBIG_NEIMA;  Q9JXI7, UBIG_NEIMB;  Q81ZZ2, UBIG_NITEU;  
Q2Y6Z3, UBIG_NITMU;  Q3J8U2, UBIG_NITOC;  Q3SVP3, UBIG_NITWN;  
A6WXQ0, UBIG_OCHA4;  A7HTX8, UBIG_PARL1;  Q9CMI6, UBIG_PASMU;  
Q6D7X5, UBIG_PECAS;  C6DBN5, UBIG_PECCP;  Q4FNA2, UBIG_PELUB;  
Q7N2M5, UBIG_PHOLL;  Q6LPD7, UBIG_PHOPR;  B4EZ30, UBIG_PROMH;  
Q48FM4, UBIG_PSE14;  A6V2Q4, UBIG_PSEA7;  B7V9J5, UBIG_PSEA8;  
Q02PX7, UBIG_PSEAB;  Q9HZ63, UBIG_PSEAE;  Q1IDA6, UBIG_PSEE4;  
Q4K8M4, UBIG_PSEF5;  C3K6J1, UBIG_PSEFS;  Q3ILA5, UBIG_PSEHT;  
A5W7G3, UBIG_PSEP1;  Q3K8T6, UBIG_PSEPF;  B0KTX4, UBIG_PSEPG;  
Q88M10, UBIG_PSEPK;  B1J5G4, UBIG_PSEPW;  Q885T9, UBIG_PSESM;  
Q4ZQ90, UBIG_PSEU2;  A4VLX7, UBIG_PSEU5;  Q4FVG3, UBIG_PSYA2;  
Q1QEI9, UBIG_PSYCK;  Q8Y0Z5, UBIG_RALSO;  B3PP83, UBIG_RHIE6;  
Q2K3S8, UBIG_RHIEC;  Q1MBA9, UBIG_RHIL3;  Q98G87, UBIG_RHILO;  
B5ZRR7, UBIG_RHILW;  Q92MK1, UBIG_RHIME;  C3MHQ9, UBIG_RHISN;  
Q21UL3, UBIG_RHOFT;  Q2J419, UBIG_RHOP2;  Q07VB6, UBIG_RHOP5;  
Q6NC69, UBIG_RHOPA;  Q21BZ6, UBIG_RHOPB;  Q13EZ9, UBIG_RHOPS;  
B3QCF3, UBIG_RHOPT;  Q2RWE9, UBIG_RHORT;  A3PNM3, UBIG_RHOS1;  
Q3IYM5, UBIG_RHOS4;  A4WW91, UBIG_RHOS5;  B9KPP7, UBIG_RHOSK;  
A8GPB1, UBIG_RICAH;  A8GX11, UBIG_RICB8;  Q1RJC7, UBIG_RICBR;  
A8EY40, UBIG_RICCK;  Q92H07, UBIG_RICCN;  Q4UME7, UBIG_RICFE;  
Q9ZCT9, UBIG_RICPR;  Q68WB5, UBIG_RICTY;  Q16D32, UBIG_ROSDO;  
Q5LWM6, UBIG_RUEPO;  Q1GCH8, UBIG_RUEST;  Q21IR9, UBIG_SACD2;  
B5EYW1, UBIG_SALA4;  A9MJY3, UBIG_SALAR;  Q57M77, UBIG_SALCH;  
B5FNR7, UBIG_SALDC;  B5R249, UBIG_SALEP;  B5RCA1, UBIG_SALG2;  
B4TBE3, UBIG_SALHS;  B4SYU8, UBIG_SALNS;  Q5PCY1, UBIG_SALPA;  
C0Q093, UBIG_SALPC;  B5BCS0, UBIG_SALPK;  B4TPG0, UBIG_SALSV;  
Q8Z560, UBIG_SALTI;  P37431, UBIG_SALTY;  A8GGX8, UBIG_SERP5;  
A1S6C9, UBIG_SHEAM;  B8EA88, UBIG_SHEB2;  A3D499, UBIG_SHEB5;  
A6WNN7, UBIG_SHEB8;  A9L2Y4, UBIG_SHEB9;  B0TT38, UBIG_SHEHH;  
Q8EEG9, UBIG_SHEON;  A8H499, UBIG_SHEPA;  A4Y759, UBIG_SHEPC;  
A0KWN3, UBIG_SHESA;  Q0HIX5, UBIG_SHESM;  Q0HV07, UBIG_SHESR;  
A1RJD1, UBIG_SHESW;  B2TW20, UBIG_SHIB3;  Q31Z65, UBIG_SHIBS;  
Q32DV8, UBIG_SHIDS;  Q0T2P9, UBIG_SHIF8;  Q820C5, UBIG_SHIFL;  
Q3YZX6, UBIG_SHISS;  A6UCF6, UBIG_SINMW;  Q2NSL7, UBIG_SODGM;  
Q31GD8, UBIG_THICR;  Q3SK91, UBIG_THIDA;  A5F1U0, UBIG_VIBC3;  
A7MU79, UBIG_VIBCB;  Q9KSJ9, UBIG_VIBCH;  C3LLV3, UBIG_VIBCM;  
Q5E5J8, UBIG_VIBF1;  B5FDT8, UBIG_VIBFM;  Q87ND5, UBIG_VIBPA;  
B7VGS0, UBIG_VIBTL;  Q8D8E0, UBIG_VIBVU;  Q7MM27, UBIG_VIBVY;  
Q8PK00, UBIG_XANAC;  Q3BSF8, UBIG_XANC5;  Q4UVL4, UBIG_XANC8;  
B0RS27, UBIG_XANCB;  Q8P8H2, UBIG_XANCP;  Q2P2C4, UBIG_XANOM;  
B2SHS9, UBIG_XANOP;  Q5GZB5, UBIG_XANOR;  B2I705, UBIG_XYLF2;  
Q9PAM5, UBIG_XYLFA;  B0U3W1, UBIG_XYLFM;  Q87BG5, UBIG_XYLFT;  
A1JLA0, UBIG_YERE8;  A7FKF4, UBIG_YERP3;  Q1C9H5, UBIG_YERPA;  
B2K9A4, UBIG_YERPB;  Q8ZGR6, UBIG_YERPE;  A9R284, UBIG_YERPG;  
Q1CFZ1, UBIG_YERPN;  A4TNI8, UBIG_YERPP;  Q66CZ4, UBIG_YERPS;  
B1JS96, UBIG_YERPY;  

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