Due to scheduled maintenance work, this service may not be available on Monday January 22nd between 08.00 am and 9.00 am CEST.
To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.1.1.244

Accepted Name
Protein N-terminal methyltransferase.
Reaction catalysed
  • 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] <=> 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
  • 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] <=> 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]
Comment(s)
  • This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved.
  • When the terminal amino acid is L-proline, the enzyme catalyzes two successive methylations of its alpha-amino group.
  • When the first amino acid is either L-alanine or L-serine, the enzyme catalyzes three successive methylations.
  • The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids.
  • Formerly EC 2.1.1.n5.
Cross-references
BRENDA2.1.1.244
EC2PDB2.1.1.244
ExplorEnz2.1.1.244
PRIAM enzyme-specific profiles2.1.1.244
KEGG Ligand Database for Enzyme Nomenclature2.1.1.244
IUBMB Enzyme Nomenclature2.1.1.244
IntEnz2.1.1.244
MEDLINEFind literature relating to 2.1.1.244
MetaCyc2.1.1.244
UniProtKB/Swiss-Prot
Q4KL94, NT1AA_XENLA;  Q4KLE6, NT1AB_XENLA;  D2H163, NTM1A_AILME;  
Q2T9N3, NTM1A_BOVIN;  Q6NWX7, NTM1A_DANRE;  Q9BV86, NTM1A_HUMAN;  
Q8R2U4, NTM1A_MOUSE;  Q5BJX0, NTM1A_RAT;  B1H2P7, NTM1A_XENTR;  
Q5PP70, NTM1_ARATH;  A8WVR2, NTM1_CAEBR;  Q9N4D9, NTM1_CAEEL;  
Q55DH6, NTM1_DICDI;  Q6NN40, NTM1_DROME;  A2XMJ1, NTM1_ORYSI;  
Q10CT5, NTM1_ORYSJ;  O13748, NTM1_SCHPO;  P38340, NTM1_YEAST;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-