ENZYME entry: EC 2.1.1.244

Accepted Name
Protein N-terminal methyltransferase.
Reaction catalysed
  • 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] <=> 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
  • 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] <=> 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]
Comment(s)
  • This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved.
  • When the terminal amino acid is L-proline, the enzyme catalyzes two successive methylations of its alpha-amino group.
  • When the first amino acid is either L-alanine or L-serine, the enzyme catalyzes three successive methylations.
  • The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids.
  • Formerly EC 2.1.1.n5.
Cross-references
BRENDA2.1.1.244
EC2PDB2.1.1.244
ExplorEnz2.1.1.244
PRIAM enzyme-specific profiles2.1.1.244
KEGG Ligand Database for Enzyme Nomenclature2.1.1.244
IUBMB Enzyme Nomenclature2.1.1.244
IntEnz2.1.1.244
MEDLINEFind literature relating to 2.1.1.244
MetaCyc2.1.1.244
UniProtKB/Swiss-Prot
Q4KL94, NT1AA_XENLA;  Q4KLE6, NT1AB_XENLA;  D2H163, NTM1A_AILME;  
Q2T9N3, NTM1A_BOVIN;  Q6NWX7, NTM1A_DANRE;  Q9BV86, NTM1A_HUMAN;  
Q8R2U4, NTM1A_MOUSE;  Q5BJX0, NTM1A_RAT;  B1H2P7, NTM1A_XENTR;  
Q5PP70, NTM1_ARATH;  A8WVR2, NTM1_CAEBR;  Q9N4D9, NTM1_CAEEL;  
Q55DH6, NTM1_DICDI;  Q6NN40, NTM1_DROME;  A2XMJ1, NTM1_ORYSI;  
Q10CT5, NTM1_ORYSJ;  O13748, NTM1_SCHPO;  P38340, NTM1_YEAST;  

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