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ENZYME entry: EC 18.104.22.1683
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|S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate <=> S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate|
- The enzyme from the bacterium Streptomyces carzinostaticus is
involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1-
- This compound is part of the enediyne chromophore of the antitumor
- In vivo the enzyme catalyzes the regiospecific methylation at the
7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1-
- In vitro it also recognizes other dihydroxynaphthoic acids and
catalyzes their regiospecific O-methylation.
|PRIAM enzyme-specific profiles||22.214.171.1243|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.1993|
|IUBMB Enzyme Nomenclature||188.8.131.523|
|MEDLINE||Find literature relating to 184.108.40.2063|
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