ENZYME entry: EC 2.1.1.303

Accepted Name
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase.
Alternative Name(s)
Neocarzinostatin O-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + 2,7-dihydroxy-5-methyl-1-naphthoate <=> S-adenosyl-L-homocysteine + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate
Comment(s)
  • The enzyme from the bacterium Streptomyces carzinostaticus is involved in the biosynthesis of 2-hydroxy-7-methoxy-5-methyl-1- naphthoate.
  • This compound is part of the enediyne chromophore of the antitumor antibiotic neocarzinostatin.
  • In vivo the enzyme catalyzes the regiospecific methylation at the 7-hydroxy group of its native substrate 2,7-dihydroxy-5-methyl-1- naphthoate.
  • In vitro it also recognizes other dihydroxynaphthoic acids and catalyzes their regiospecific O-methylation.
Cross-references
BRENDA2.1.1.303
EC2PDB2.1.1.303
ExplorEnz2.1.1.303
PRIAM enzyme-specific profiles2.1.1.303
KEGG Ligand Database for Enzyme Nomenclature2.1.1.303
IUBMB Enzyme Nomenclature2.1.1.303
IntEnz2.1.1.303
MEDLINEFind literature relating to 2.1.1.303
MetaCyc2.1.1.303
UniProtKB/Swiss-Prot
Q84HC8, NCSB1_STRCZ

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-