ENZYME entry: EC 2.1.1.70

Accepted Name
8-hydroxyfuranocoumarin 8-O-methyltransferase.
Alternative Name(s)
Furanocoumarin 8-methyltransferase.
Furanocoumarin 8-O-methyl-transferase.
Xanthotoxol 8-O-methyltransferase.
XMT.
Reaction catalysed
  • S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin <=> S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin
  • S-adenosyl-L-methionine + xanthotoxol <=> S-adenosyl-L-homocysteine + xanthotoxin
Comment(s)
  • Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities.
  • Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols.
  • See also EC 2.1.1.69.
  • Formerly EC 2.1.1.93.
Cross-references
BRENDA2.1.1.70
EC2PDB2.1.1.70
ExplorEnz2.1.1.70
PRIAM enzyme-specific profiles2.1.1.70
KEGG Ligand Database for Enzyme Nomenclature2.1.1.70
IUBMB Enzyme Nomenclature2.1.1.70
IntEnz2.1.1.70
MEDLINEFind literature relating to 2.1.1.70
MetaCyc2.1.1.70

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