ENZYME entry: EC 2.1.1.98

Accepted Name
Diphthine synthase.
Reaction catalysed
3 S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] <=> 3 S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(trimethylammonio)propyl)-L-histidine-[translation elongation factor 2]
Comment(s)
The trimethylated product, diphthine, is converted into diphthamide by EC 6.3.1.14.
Cross-references
BRENDA2.1.1.98
EC2PDB2.1.1.98
ExplorEnz2.1.1.98
PRIAM enzyme-specific profiles2.1.1.98
KEGG Ligand Database for Enzyme Nomenclature2.1.1.98
IUBMB Enzyme Nomenclature2.1.1.98
IntEnz2.1.1.98
MEDLINEFind literature relating to 2.1.1.98
MetaCyc2.1.1.98
UniProtKB/Swiss-Prot
O81769, DPH5_ARATH;  Q754E7, DPH5_ASHGO;  Q6MY91, DPH5_ASPFU;  
Q5E982, DPH5_BOVIN;  Q59NX9, DPH5_CANAL;  Q6FXK9, DPH5_CANGA;  
Q6BN80, DPH5_DEBHA;  Q75JG8, DPH5_DICDI;  Q5BFG0, DPH5_EMENI;  
Q4HZI0, DPH5_GIBZE;  Q9H2P9, DPH5_HUMAN;  Q6CIZ1, DPH5_KLULA;  
Q9CWQ0, DPH5_MOUSE;  Q7S949, DPH5_NEUCR;  O74898, DPH5_SCHPO;  
Q6C1E0, DPH5_YARLI;  P32469, DPH5_YEAST;  Q9YDI2, DPHB_AERPE;  
O29866, DPHB_ARCFU;  B9LV13, DPHB_HALLT;  Q5V2B7, DPHB_HALMA;  
B0R4W9, DPHB_HALS3;  Q9HQK6, DPHB_HALSA;  Q18JS3, DPHB_HALWD;  
A6UU49, DPHB_META3;  Q8TR14, DPHB_METAC;  A7IA21, DPHB_METB6;  
Q467Z4, DPHB_METBF;  Q12XB4, DPHB_METBU;  Q2FQ45, DPHB_METHJ;  
Q58670, DPHB_METJA;  Q8TXC7, DPHB_METKA;  A2SQF6, DPHB_METLZ;  
A4FYP1, DPHB_METM5;  A9A6D8, DPHB_METM6;  A6VJP1, DPHB_METM7;  
Q8PUH9, DPHB_METMA;  A3CWF9, DPHB_METMJ;  Q6LZN6, DPHB_METMP;  
B8GIF8, DPHB_METPE;  A4YHI8, DPHB_METS5;  Q2NFJ8, DPHB_METST;  
O27902, DPHB_METTH;  A0B879, DPHB_METTP;  A6US81, DPHB_METVS;  
Q3IS55, DPHB_NATPD;  Q9UZ31, DPHB_PYRAB;  Q8ZXR9, DPHB_PYRAE;  
A3MU14, DPHB_PYRCJ;  Q8U377, DPHB_PYRFU;  O58456, DPHB_PYRHO;  
A1RU15, DPHB_PYRIL;  B1YAU2, DPHB_PYRNV;  A3DLV7, DPHB_STAMF;  
C3N5D1, DPHB_SULIA;  C4KGZ7, DPHB_SULIK;  C3MPQ5, DPHB_SULIL;  
C3MYP9, DPHB_SULIM;  C3NHR8, DPHB_SULIN;  C3NDY5, DPHB_SULIY;  
Q97TX8, DPHB_SULSO;  Q971V1, DPHB_SULTO;  Q9HJT0, DPHB_THEAC;  
C5A3K4, DPHB_THEGJ;  Q5JFE7, DPHB_THEKO;  B6YXP9, DPHB_THEON;  
Q979Z8, DPHB_THEVO;  Q0W085, DPHB_UNCMA;  

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