ENZYME entry: EC 2.1.1.98

Accepted Name
Diphthine synthase.
Reaction catalysed
3 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine-[translation elongation factor 2] <=> 3 S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2]
Comment(s)
  • This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14.
  • Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314).
  • In the archaeon Pyrococcus horikoshii the enzyme acts on His(600) of elongation factor 2.
Cross-references
BRENDA2.1.1.98
EC2PDB2.1.1.98
ExplorEnz2.1.1.98
PRIAM enzyme-specific profiles2.1.1.98
KEGG Ligand Database for Enzyme Nomenclature2.1.1.98
IUBMB Enzyme Nomenclature2.1.1.98
IntEnz2.1.1.98
MEDLINEFind literature relating to 2.1.1.98
MetaCyc2.1.1.98
UniProtKB/Swiss-Prot
Q9YDI2, DPHB_AERPE;  O29866, DPHB_ARCFU;  B9LV13, DPHB_HALLT;  
Q5V2B7, DPHB_HALMA;  B0R4W9, DPHB_HALS3;  Q9HQK6, DPHB_HALSA;  
Q18JS3, DPHB_HALWD;  A6UU49, DPHB_META3;  Q8TR14, DPHB_METAC;  
Q0W085, DPHB_METAR;  A7IA21, DPHB_METB6;  Q467Z4, DPHB_METBF;  
Q12XB4, DPHB_METBU;  Q2FQ45, DPHB_METHJ;  Q58670, DPHB_METJA;  
Q8TXC7, DPHB_METKA;  A2SQF6, DPHB_METLZ;  A4FYP1, DPHB_METM5;  
A9A6D8, DPHB_METM6;  A6VJP1, DPHB_METM7;  Q8PUH9, DPHB_METMA;  
A3CWF9, DPHB_METMJ;  Q6LZN6, DPHB_METMP;  B8GIF8, DPHB_METPE;  
A4YHI8, DPHB_METS5;  Q2NFJ8, DPHB_METST;  O27902, DPHB_METTH;  
A0B879, DPHB_METTP;  A6US81, DPHB_METVS;  Q3IS55, DPHB_NATPD;  
Q9UZ31, DPHB_PYRAB;  Q8ZXR9, DPHB_PYRAE;  A3MU14, DPHB_PYRCJ;  
Q8U377, DPHB_PYRFU;  O58456, DPHB_PYRHO;  A1RU15, DPHB_PYRIL;  
B1YAU2, DPHB_PYRNV;  A3DLV7, DPHB_STAMF;  C3N5D1, DPHB_SULIA;  
C4KGZ7, DPHB_SULIK;  C3MPQ5, DPHB_SULIL;  C3MYP9, DPHB_SULIM;  
C3NHR8, DPHB_SULIN;  C3NDY5, DPHB_SULIY;  Q97TX8, DPHB_SULSO;  
Q971V1, DPHB_SULTO;  Q9HJT0, DPHB_THEAC;  C5A3K4, DPHB_THEGJ;  
Q5JFE7, DPHB_THEKO;  B6YXP9, DPHB_THEON;  Q979Z8, DPHB_THEVO;  

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