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ENZYME entry: EC

Accepted Name
Diphthine--ammonia ligase.
Alternative Name(s)
Diphthamide synthase.
Diphthamide synthetase.
Reaction catalysed
ATP + diphthine-[translation elongation factor 2] + NH(3) <=> AMP + diphosphate + diphthamide-[translation elongation factor 2]
  • This amidase catalyzes the last step in the conversion of an L-histidine residue in the translation elongation factor translation elongation factor 2 to diphthamide.
  • This factor is found in all archaebacteria and eukaryotes, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC
  • The substrate of the enzyme, diphthine, is produced by EC
  • Formerly EC
PRIAM enzyme-specific profiles6.3.1.14
KEGG Ligand Database for Enzyme Nomenclature6.3.1.14
IUBMB Enzyme Nomenclature6.3.1.14
MEDLINEFind literature relating to
Q12429, DPH6_YEAST;  

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