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ENZYME entry: EC 22.214.171.124
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|Alpha-(1,3/1,4) fucosyltransferase III.|
|Blood group Lewis alpha-4-fucosyltransferase.|
|Blood-group substance Le(a)-dependent fucosyltransferase.|
|Guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-
|Guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase.|
|Guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase.|
|Lewis blood group alpha-(1->3/4)-fucosyltransferase.|
|Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase.|
|GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R <=> GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R|
- Product of the Lewis blood group gene.
- Normally acts on a glycoconjugate where R (see CA line) is a
glycoprotein or glycolipid.
- Although it is a 4-fucosyltransferase, it has a persistent
3-fucosyltransferase activity toward the glucose residue in free
- Fucosylates on O-4 of an N-acetylglucosamine that carries a
galactosyl group on O-3, unlike EC 126.96.36.199 which fucosylates on O-3
of an N-acetylglucosamine that carries a galactosyl group on O-4.
- Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D-
Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha-
fucosyltransferases) are present in plants, where the function in
vivo is the modification of N-glycans.
- In addition, the fucTa gene of Helicobacter strain UA948 encodes a
fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase
|PRIAM enzyme-specific profiles||188.8.131.52|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.206|
|IUBMB Enzyme Nomenclature||220.127.116.11|
|MEDLINE||Find literature relating to 18.104.22.168|
|Q11126, FUT3_BOVIN; ||P21217, FUT3_HUMAN; ||O19058, FUT3_PANTR; |
|Q8HYJ5, FUT3_PONPY; ||Q8HYJ7, FUT5_GORGO; ||Q11128, FUT5_HUMAN; |
|Q8HYJ3, FUT5_HYLLA; ||P56433, FUT5_PANTR; ||Q8HYJ4, FUT5_PONPY; |
|Q8HYJ6, FUT6_GORGO; ||P51993, FUT6_HUMAN; ||P56434, FUT6_PANTR; |
|Q9GKU6, FUT6_PONPY; ||G5EFP5, FUTC_CAEEL; ||G5EE06, FUTD_CAEEL; |
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