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ENZYME entry: EC 2.4.1.65

Accepted Name
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase.
Alternative Name(s)
(Le(a))-dependent (alpha-3/4)-fucosyltransferase.
Alpha-(1,3/1,4) fucosyltransferase III.
Alpha-(1->4)-L-fucosyltransferase.
Alpha-4-L-fucosyltransferase.
Beta-acetylglucosaminylsaccharide fucosyltransferase.
Blood group Lewis alpha-4-fucosyltransferase.
Blood-group substance Le(a)-dependent fucosyltransferase.
FucT-II.
Galactoside 3(4)-L-fucosyltransferase.
Guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L- fucosyltransferase.
Guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase.
Guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase.
Lewis alpha-(1->3/4)-fucosyltransferase.
Lewis blood group alpha-(1->3/4)-fucosyltransferase.
Lewis FT.
Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase.
Reaction catalysed
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R <=> GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R
Comment(s)
  • Product of the Lewis blood group gene.
  • Normally acts on a glycoconjugate where R (see CA line) is a glycoprotein or glycolipid.
  • Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity toward the glucose residue in free lactose.
  • Fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152 which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4.
  • Enzymes catalyzing the 4-alpha-fucosylation of the GlcNAc in beta-D- Gal-(1->3)-beta-GlcNAc sequences (with some activity also as 3-alpha- fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans.
  • In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-alpha- and 4-alpha-fucosyltransferase activities.
Cross-references
BRENDA2.4.1.65
EC2PDB2.4.1.65
ExplorEnz2.4.1.65
PRIAM enzyme-specific profiles2.4.1.65
KEGG Ligand Database for Enzyme Nomenclature2.4.1.65
IUBMB Enzyme Nomenclature2.4.1.65
IntEnz2.4.1.65
MEDLINEFind literature relating to 2.4.1.65
MetaCyc2.4.1.65
UniProtKB/Swiss-Prot
Q11126, FUT3_BOVIN;  P21217, FUT3_HUMAN;  O19058, FUT3_PANTR;  
Q8HYJ5, FUT3_PONPY;  Q8HYJ7, FUT5_GORGO;  Q11128, FUT5_HUMAN;  
Q8HYJ3, FUT5_HYLLA;  P56433, FUT5_PANTR;  Q8HYJ4, FUT5_PONPY;  
Q8HYJ6, FUT6_GORGO;  P51993, FUT6_HUMAN;  P56434, FUT6_PANTR;  
Q9GKU6, FUT6_PONPY;  G5EFP5, FUTC_CAEEL;  G5EE06, FUTD_CAEEL;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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