ENZYME entry: EC 2.7.1.25

Accepted Name
Adenylyl-sulfate kinase.
Alternative Name(s)
Adenosine 5'-phosphosulfate kinase.
Adenylylsulfate kinase.
APS kinase.
Reaction catalysed
ATP + adenylyl sulfate <=> ADP + 3'-phosphoadenylyl sulfate
Comment(s)
  • The human phosphoadenosine-phosphosulfate synthase (PAPS) system is a bifunctional enzyme: ATP sulfurylase, which catalyzes the formation of adenosine 5'-phosphosulfate (APS) from ATP and inorganic sulfate and the second step is catalyzed by the APS kinase portion of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase, which involves the formation of PAPS from enzyme bound APS and ATP.
  • This is in contrast to what is found in bacteria, yeasts, fungi and plants, where the formation of PAPS is carried out by two individual polypeptides, EC 2.7.7.4 and EC 2.7.1.25.
Cross-references
BRENDA2.7.1.25
EC2PDB2.7.1.25
ExplorEnz2.7.1.25
PRIAM enzyme-specific profiles2.7.1.25
KEGG Ligand Database for Enzyme Nomenclature2.7.1.25
IUBMB Enzyme Nomenclature2.7.1.25
IntEnz2.7.1.25
MEDLINEFind literature relating to 2.7.1.25
MetaCyc2.7.1.25
UniProtKB/Swiss-Prot
Q43295, APK1_ARATH;  O49196, APK2_ARATH;  Q9SRW7, APK3_ARATH;  
Q84JF0, APK4_ARATH;  Q9KCT0, CYSC1_BACHD;  O34577, CYSC1_BACSU;  
Q9K7H6, CYSC2_BACHD;  O06735, CYSC2_BACSU;  B0CAX3, CYSC_ACAM1;  
A0KP33, CYSC_AERHH;  Q9YCR6, CYSC_AERPE;  A4SRG6, CYSC_AERS4;  
O29953, CYSC_ARCFU;  A7Z4I0, CYSC_BACA2;  Q5LES5, CYSC_BACFN;  
Q64VR1, CYSC_BACFR;  Q65JT8, CYSC_BACLD;  A8FD25, CYSC_BACP2;  
Q8AAQ1, CYSC_BACTN;  A6KXG9, CYSC_BACV8;  P57497, CYSC_BUCAI;  
Q8K9D4, CYSC_BUCAP;  Q0BI00, CYSC_BURCM;  B2T3K5, CYSC_BURPP;  
Q13ZJ7, CYSC_BURXL;  B9LKC1, CYSC_CHLSY;  A8ANW4, CYSC_CITK8;  
Q97MT8, CYSC_CLOAB;  A5N960, CYSC_CLOK5;  A7MJ70, CYSC_CROS8;  
B7K8N5, CYSC_CYAP7;  B7K5B1, CYSC_CYAP8;  C1CVW7, CYSC_DEIDV;  
Q1IYI1, CYSC_DEIGD;  P56861, CYSC_DEIRA;  A7ZQJ4, CYSC_ECO24;  
B7UHG9, CYSC_ECO27;  B7MKM4, CYSC_ECO45;  B7LEG8, CYSC_ECO55;  
P0A6J2, CYSC_ECO57;  B5Z3B2, CYSC_ECO5E;  B7NT94, CYSC_ECO7I;  
B7MYQ5, CYSC_ECO81;  B7LXG2, CYSC_ECO8A;  C4ZZQ4, CYSC_ECOBW;  
B1XCS6, CYSC_ECODH;  A8A3M9, CYSC_ECOHS;  A1AEU4, CYSC_ECOK1;  
Q0TEA8, CYSC_ECOL5;  Q8FEJ2, CYSC_ECOL6;  B1IUS9, CYSC_ECOLC;  
P0A6J1, CYSC_ECOLI;  B7N6Y0, CYSC_ECOLU;  B6I6E0, CYSC_ECOSE;  
B1LQ71, CYSC_ECOSM;  Q1R7U1, CYSC_ECOUT;  A4WDV5, CYSC_ENT38;  
B2VG00, CYSC_ERWT9;  B7LWK5, CYSC_ESCF3;  B9M543, CYSC_GEODF;  
A5G863, CYSC_GEOUR;  B8D0S4, CYSC_HALOH;  B5XV31, CYSC_KLEP3;  
A6TD42, CYSC_KLEP7;  Q88X60, CYSC_LACPL;  A1U3X8, CYSC_MARHV;  
B0JL16, CYSC_MICAN;  Q1D6P1, CYSC_MYXXD;  Q8EQN3, CYSC_OCEIH;  
Q7VE24, CYSC_PROMA;  P57702, CYSC_PSEAE;  P29811, CYSC_PSEAI;  
Q1I2K4, CYSC_PSEE4;  P56858, CYSC_PYRAB;  Q7UQW3, CYSC_RHOBA;  
B5F414, CYSC_SALA4;  A9MF25, CYSC_SALAR;  Q57KJ1, CYSC_SALCH;  
B5FTS8, CYSC_SALDC;  B5QW21, CYSC_SALEP;  B5RDQ6, CYSC_SALG2;  
B4TFX0, CYSC_SALHS;  B4T460, CYSC_SALNS;  Q5PEH3, CYSC_SALPA;  
A9N2D7, CYSC_SALPB;  C0PXB0, CYSC_SALPC;  B5BEY7, CYSC_SALPK;  
B4TTW4, CYSC_SALSV;  P63890, CYSC_SALTI;  P63889, CYSC_SALTY;  
A1S9N4, CYSC_SHEAM;  B8EE63, CYSC_SHEB2;  A3D819, CYSC_SHEB5;  
A6WJU6, CYSC_SHEB8;  A9L392, CYSC_SHEB9;  Q12QM6, CYSC_SHEDO;  
Q07Y94, CYSC_SHEFN;  B0TTD2, CYSC_SHEHH;  Q8EB13, CYSC_SHEON;  
A8H0A6, CYSC_SHEPA;  A4Y9X0, CYSC_SHEPC;  A0KTI5, CYSC_SHESA;  
Q0HFM7, CYSC_SHESM;  Q0HYA3, CYSC_SHESR;  A1RGG0, CYSC_SHESW;  
B2TZI1, CYSC_SHIB3;  Q31XB2, CYSC_SHIBS;  Q32CI0, CYSC_SHIDS;  
Q0T1I1, CYSC_SHIF8;  Q83JX9, CYSC_SHIFL;  Q3YYB2, CYSC_SHISS;  
B9DLK2, CYSC_STACT;  Q5HL02, CYSC_STAEQ;  Q8CR04, CYSC_STAES;  
Q4L9E6, CYSC_STAHJ;  Q49UM5, CYSC_STAS1;  Q2JUC0, CYSC_SYNJA;  
Q2JLM3, CYSC_SYNJB;  B1XN05, CYSC_SYNP2;  P72940, CYSC_SYNY3;  
Q8DJ87, CYSC_THEEB;  B5YJA6, CYSC_THEYD;  Q9KP21, CYSC_VIBCH;  
Q87SX6, CYSC_VIBPA;  Q8DE75, CYSC_VIBVU;  Q7MPF0, CYSC_VIBVY;  
Q8ZBP3, CYSC_YERPE;  P9WNM4, CYSNC_MYCTO;  P9WNM5, CYSNC_MYCTU;  
O50274, CYSNC_PSEAE;  Q7UMW2, CYSNC_RHOBA;  Q9PD78, CYSNC_XYLFA;  
Q87DG7, CYSNC_XYLFT;  O49204, KAPS_CATRO;  Q92203, KAPS_EMENI;  
Q12657, KAPS_PENCH;  Q9HGF8, KAPS_SACBA;  Q9C2Y6, KAPS_SACPS;  
Q9P7G9, KAPS_SCHPO;  Q02196, KAPS_YEAST;  P28604, NODQ_AZOBR;  
P13442, NODQ_RHIME;  P72339, NODQ_RHIS3;  O07309, NODQ_RHISB;  
P52978, NODQ_RHITR;  O54820, PAPS1_CAVPO;  O43252, PAPS1_HUMAN;  
Q60967, PAPS1_MOUSE;  O95340, PAPS2_HUMAN;  O88428, PAPS2_MOUSE;  
Q27128, PAPSS_URECA;  A9ENT2, SATC1_SORC5;  A9G7W0, SATC2_SORC5;  
O67174, SATC_AQUAE;  

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