ENZYME

ENZYME entry: EC 2.8.2.29

Accepted Name

[Heparan sulfate]-glucosamine 3-sulfotransferase 2.

Alternative Name(s)

3-OST-2.

Glucosaminyl 3-O-sulfotransferase 2.

Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2.

Reaction catalysed

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine <=> adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate

Comment(s)

This enzyme sulfates the residues marked with an asterisk in sequences containing at least ->IdoA2S->GlcN*-> or ->GlcA2S->GlcN*->.
Preference for GlcN2S versus unmodified GlcN has not yet been established.
Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant.
This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC 2.8.2.23 prefers GlcA or IdoA, whereas EC 2.8.2.30 prefers IdoA2S.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature