ENZYME entry: EC 2.8.2.29

Accepted Name
[Heparan sulfate]-glucosamine 3-sulfotransferase 2.
Alternative Name(s)
3-OST-2.
Glucosaminyl 3-O-sulfotransferase 2.
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2.
Reaction catalysed
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine <=> adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
Comment(s)
  • This enzyme sulfates the residues marked with an asterisk in sequences containing at least ->IdoA2S->GlcN*-> or ->GlcA2S->GlcN*->.
  • Preference for GlcN2S versus unmodified GlcN has not yet been established.
  • Additional structural features are presumably required for substrate recognition, since the 3-O-sulfated residue is of low abundance, whereas the above IdoA-containing sequence is quite abundant.
  • This enzyme differs from the other [heparan sulfate]-glucosamine 3-sulfotransferases by modifying selected glucosamine residues preceded by GlcA2S; EC 2.8.2.23 prefers GlcA or IdoA, whereas EC 2.8.2.30 prefers IdoA2S.
Cross-references
BRENDA2.8.2.29
EC2PDB2.8.2.29
ExplorEnz2.8.2.29
PRIAM enzyme-specific profiles2.8.2.29
KEGG Ligand Database for Enzyme Nomenclature2.8.2.29
IUBMB Enzyme Nomenclature2.8.2.29
IntEnz2.8.2.29
MEDLINEFind literature relating to 2.8.2.29
MetaCyc2.8.2.29
UniProtKB/Swiss-Prot
Q9Y278, HS3S2_HUMAN;  Q673U1, HS3S2_MOUSE;  Q80W66, HS3S2_RAT;  

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