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ENZYME entry: EC 126.96.36.199
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|[Heparan sulfate]-glucosamine 3-sulfotransferase 3.
|Glucosaminyl 3-O-sulfotransferase 3.|
|Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3.|
|3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine <=> adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate|
- Two major substrates contain the tetrasaccharides: -> undetermined
2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN*-> and -> undetermined
2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN6S*-> with modification of
the N-unsubstituted glucosamine residue (shown with an asterisk).
- Modification of selected sequences containing N-sulfo-glucosamine
residues cannot yet be excluded.
- The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex
virus type 1 as an entry receptor to infect the target cells.
- There are two isozymes, known as 3-OST-3(A) and 3-OST-3(B), which
have identical catalytic domains but are encoded by different
- The specificity of this enzyme differs from that of the other
[heparan sulfate]-glucosamine 3-sulfotransferases.
- It is inefficient at modifying precursors of the antithrombin binding
site (in contrast to EC 188.8.131.52) and it does not modify glucosamine
preceded by GlcA2S (unlike EC 184.108.40.206).
|PRIAM enzyme-specific profiles||220.127.116.11|
|KEGG Ligand Database for Enzyme Nomenclature||18.104.22.168|
|IUBMB Enzyme Nomenclature||22.214.171.124|
|MEDLINE||Find literature relating to 126.96.36.199|
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