To improve security and privacy, we are moving our web pages and services from HTTP to HTTPS.
To give users of web services time to transition to HTTPS, we will support separate HTTP and HTTPS services until the end of 2017.
From January 2018 most HTTP traffic will be automatically redirected to HTTPS. [more...]
View this page in https

ENZYME entry: EC 2.8.2.30

Accepted Name
[Heparan sulfate]-glucosamine 3-sulfotransferase 3.
Alternative Name(s)
3-OST-3.
Glucosaminyl 3-O-sulfotransferase 3.
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3.
Reaction catalysed
3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine <=> adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate
Comment(s)
  • Two major substrates contain the tetrasaccharides: -> undetermined 2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN*-> and -> undetermined 2-sulfo-uronic acid->GlcN2S->IdoA2S->GlcN6S*-> with modification of the N-unsubstituted glucosamine residue (shown with an asterisk).
  • Modification of selected sequences containing N-sulfo-glucosamine residues cannot yet be excluded.
  • The 3-O-sulfated heparan sulfate can be utilized by Herpes simplex virus type 1 as an entry receptor to infect the target cells.
  • There are two isozymes, known as 3-OST-3(A) and 3-OST-3(B), which have identical catalytic domains but are encoded by different mammalian genes.
  • The specificity of this enzyme differs from that of the other [heparan sulfate]-glucosamine 3-sulfotransferases.
  • It is inefficient at modifying precursors of the antithrombin binding site (in contrast to EC 2.8.2.23) and it does not modify glucosamine preceded by GlcA2S (unlike EC 2.8.2.29).
Cross-references
BRENDA2.8.2.30
EC2PDB2.8.2.30
ExplorEnz2.8.2.30
PRIAM enzyme-specific profiles2.8.2.30
KEGG Ligand Database for Enzyme Nomenclature2.8.2.30
IUBMB Enzyme Nomenclature2.8.2.30
IntEnz2.8.2.30
MEDLINEFind literature relating to 2.8.2.30
MetaCyc2.8.2.30
UniProtKB/Swiss-Prot
Q9Y663, HS3SA_HUMAN;  Q9Y662, HS3SB_HUMAN;  Q9QZS6, HS3SB_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.8.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-