ENZYME entry: EC 3.1.3.36

Accepted Name
Phosphoinositide 5-phosphatase.
Alternative Name(s)
Diphosphoinositide phosphatase.
Inositol 1,4,5-triphosphate 5-phosphomonoesterase.
Inositol triphosphate 5-phosphomonoesterase.
IP(3) phosphatase.
Phosphatidyl-inositol-bisphosphate phosphatase.
Phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase.
Phosphatidylinositol 4,5-bisphosphate phosphatase.
Phosphatidylinositol-bisphosphatase.
Polyphosphoinositol lipid 5-phosphatase.
PtdIns(4,5)P(2) phosphatase.
Triphosphoinositide phosphatase.
Triphosphoinositide phosphomonoesterase.
Type II inositol polyphosphate 5-phosphatase.
Type II inositol-1,4,5-trisphosphate 5-phosphatase.
Reaction catalysed
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O <=> 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Comment(s)
  • These enzymes can also remove the 5-phosphate from Ins(1,4,5)P(3) and/or Ins(1,3,4,5)P(4).
  • They are a diverse family of enzymes, with differing abilities to catalyze two or more of the four reactions listed.
  • They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo.
  • All of them can use either or both of PtdIns(4,5)P(2) and PtdIns(3,4,5)P(3) as substrates; this is the main property that distinguishes them from EC 3.1.3.56.
Cross-references
BRENDA3.1.3.36
EC2PDB3.1.3.36
ExplorEnz3.1.3.36
PRIAM enzyme-specific profiles3.1.3.36
KEGG Ligand Database for Enzyme Nomenclature3.1.3.36
IUBMB Enzyme Nomenclature3.1.3.36
IntEnz3.1.3.36
MEDLINEFind literature relating to 3.1.3.36
MetaCyc3.1.3.36
UniProtKB/Swiss-Prot
P32019, I5P2_HUMAN;  Q8K337, I5P2_MOUSE;  P40559, INP51_YEAST;  
P50942, INP52_YEAST;  Q12271, INP53_YEAST;  Q08227, INP54_YEAST;  
Q9NRR6, INP5E_HUMAN;  Q9JII1, INP5E_MOUSE;  A0FI79, INP5E_PANTR;  
Q9WVR1, INP5E_RAT;  Q84W55, IP5P4_ARATH;  Q9SKB7, IP5PE_ARATH;  
Q01968, OCRL_HUMAN;  Q6NVF0, OCRL_MOUSE;  D3ZGS3, OCRL_RAT;  
O43001, SYJ1_SCHPO;  Q9USQ6, SYJ2_SCHPO;  O18964, SYNJ1_BOVIN;  
O43426, SYNJ1_HUMAN;  Q8CHC4, SYNJ1_MOUSE;  Q62910, SYNJ1_RAT;  
O15056, SYNJ2_HUMAN;  Q9D2G5, SYNJ2_MOUSE;  O55207, SYNJ2_RAT;  

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