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ENZYME

ENZYME entry: EC 3.1.3.78

PURL: https://purl.expasy.org/enzyme/EC/3.1.3.78
Accepted Name
phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Alternative Name(s)
PtdIns-4,5-P2 4-phosphatase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
Comment(s)
  • Two pathways exist in mammalian cells to degrade 1-phosphatidyl- 1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2].
  • One is catalyzed by this enzyme and the other by EC 3.1.3.36, where the product is PtdIns4P.
  • The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P.
  • In humans, the enzyme is localized to late endosomal/lysosomal membranes.
  • It can control nuclear levels of PtdIns5P and thereby control p53- dependent apoptosis.
  • Formerly EC 3.1.3.n3.
Cross-references
BRENDA3.1.3.78
EC2PDB3.1.3.78
ExplorEnz3.1.3.78
KEGG Ligand Database for Enzyme Nomenclature3.1.3.78
IUBMB Enzyme Nomenclature3.1.3.78
MEDLINEFind literature relating to 3.1.3.78
MetaCyc3.1.3.78
Rhea expert-curated reactions3.1.3.78
UniProtKB/Swiss-Prot
Q07566, IPGD_SHIFLQ55286, IPGD_SHISOQ86T03, PP4P1_HUMAN
Q4R6W2, PP4P1_MACFAQ3TWL2, PP4P1_MOUSEQ5PPM8, PP4P1_RAT
Q5XKA6, PP4P1_XENLAQ3SZ48, PP4P2_BOVINQ8N4L2, PP4P2_HUMAN
Q9CZX7, PP4P2_MOUSEQ4V888, PP4P2_RATQ5EAU3, PP4P2_XENLA
Q6DIE4, PP4P2_XENTRQ32PR0, T55BA_DANREQ66I51, T55BB_DANRE

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