ENZYME entry: EC 3.1.4.53

Accepted Name
3',5'-cyclic-AMP phosphodiesterase.
Alternative Name(s)
cAMP-specific PDE.
cAMP-specific phosphodiesterase.
Reaction catalysed
Adenosine 3',5'-cyclic phosphate + H(2)O <=> adenosine 5'-phosphate
Comment(s)
  • Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35).
  • It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation.
  • Formerly EC 3.1.4.n1.
Cross-references
PROSITEPDOC00116
BRENDA3.1.4.53
EC2PDB3.1.4.53
ExplorEnz3.1.4.53
PRIAM enzyme-specific profiles3.1.4.53
KEGG Ligand Database for Enzyme Nomenclature3.1.4.53
IUBMB Enzyme Nomenclature3.1.4.53
IntEnz3.1.4.53
MEDLINEFind literature relating to 3.1.4.53
MetaCyc3.1.4.53
UniProtKB/Swiss-Prot
P12019, PDE1_DICDI;  Q23917, PDE2_DICDI;  O89085, PDE4A_CAVPO;  
Q9W4T4, PDE4A_DROME;  P27815, PDE4A_HUMAN;  O89084, PDE4A_MOUSE;  
P54748, PDE4A_RAT;  P12252, PDE4B_DROME;  Q07343, PDE4B_HUMAN;  
P14646, PDE4B_RAT;  Q9W4S9, PDE4C_DROME;  Q08493, PDE4C_HUMAN;  
Q3UEI1, PDE4C_MOUSE;  P14644, PDE4C_RAT;  Q9W4T0, PDE4D_DROME;  
Q08499, PDE4D_HUMAN;  Q01063, PDE4D_MOUSE;  P14270, PDE4D_RAT;  
Q8IRU4, PDE4E_DROME;  Q86H13, PDE4_DICDI;  Q8MM62, PDE6_DICDI;  
Q13946, PDE7A_HUMAN;  P70453, PDE7A_MOUSE;  O08593, PDE7A_RAT;  
Q9NP56, PDE7B_HUMAN;  Q9QXQ1, PDE7B_MOUSE;  Q54HY0, PDE7_DICDI;  
O60658, PDE8A_HUMAN;  O88502, PDE8A_MOUSE;  O95263, PDE8B_HUMAN;  
E9Q4S1, PDE8B_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.1.4.-
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