ENZYME entry: EC 3.2.2.5

Accepted Name
NAD(+) glycohydrolase.
Alternative Name(s)
ADP-ribosyl cyclase.
Beta-NAD(+) glycohydrolase.
Diphosphopyridine nucleosidase.
DPN hydrolase.
DPNase.
NAD glycohydrolase.
NAD nucleosidase.
NAD(+) nucleosidase.
NADase.
Nicotinamide adenine dinucleotide glycohydrolase.
Nicotinamide adenine dinucleotide nucleosidase.
Reaction catalysed
NAD(+) + H(2)O <=> ADP-D-ribose + nicotinamide
Comment(s)
  • This enzyme catalyzes the hydrolysis of NAD(+), without associated ADP-ribosyl transferase or ADP-ribosyl cyclase activities (unlike the metazoan enzyme EC 3.2.2.6, bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
  • The enzyme from Group A streptococci has been implicated in the pathogenesis of diseases such as streptococcal toxic shock-like syndrome (STSS) and necrotizing fasciitis.
  • The enzyme from the venom of the snake Agkistrodon acutus also catalyzes EC 3.6.1.5.
Cross-references
BRENDA3.2.2.5
EC2PDB3.2.2.5
ExplorEnz3.2.2.5
PRIAM enzyme-specific profiles3.2.2.5
KEGG Ligand Database for Enzyme Nomenclature3.2.2.5
IUBMB Enzyme Nomenclature3.2.2.5
IntEnz3.2.2.5
MEDLINEFind literature relating to 3.2.2.5
MetaCyc3.2.2.5
UniProtKB/Swiss-Prot
Q10588, BST1_HUMAN;  Q64277, BST1_MOUSE;  Q63072, BST1_RAT;  
P28907, CD38_HUMAN;  Q5VAN0, CD38_MACFA;  P56528, CD38_MOUSE;  
Q9MZ03, CD38_RABIT;  Q64244, CD38_RAT;  P29241, NADA_APLCA;  
Q27312, NADA_APLKU;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.2.2.-
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