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ENZYME entry: EC 184.108.40.206
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|Nicotinamide adenine dinucleotide glycohydrolase.|
|Nicotinamide adenine dinucleotide nucleosidase.|
|NAD(+) + H(2)O <=> ADP-D-ribose + nicotinamide|
- This enzyme catalyzes the hydrolysis of NAD(+), without associated
ADP-ribosyl cyclase activity (unlike the metazoan enzyme EC 220.127.116.11,
bifunctional ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase).
- The enzyme from Group A streptococci has been implicated in the
pathogenesis of diseases such as streptococcal toxic shock-like
syndrome (STSS) and necrotizing fasciitis.
- The enzyme from the venom of the snake Agkistrodon acutus also
catalyzes EC 18.104.22.168.
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
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entries corresponding to 3.2.2.-
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