ENZYME entry: EC 3.2.2.6

Accepted Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
Alternative Name(s)
NAD hydrolase.
NAD(+) nucleosidase.
NADase.
Nicotinamide adenine dinucleotide nucleosidase.
Reaction catalysed
NAD(+) + H(2)O <=> ADP-D-ribose + nicotinamide
Comment(s)
  • This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes.
  • In addition, the enzyme also catalyzes EC 2.4.99.20.
  • Cf. EC 3.2.2.5.
Cross-references
BRENDA3.2.2.6
EC2PDB3.2.2.6
ExplorEnz3.2.2.6
PRIAM enzyme-specific profiles3.2.2.6
KEGG Ligand Database for Enzyme Nomenclature3.2.2.6
IUBMB Enzyme Nomenclature3.2.2.6
IntEnz3.2.2.6
MEDLINEFind literature relating to 3.2.2.6
MetaCyc3.2.2.6
UniProtKB/Swiss-Prot
Q10588, BST1_HUMAN;  Q64277, BST1_MOUSE;  Q63072, BST1_RAT;  
P28907, CD38_HUMAN;  Q5VAN0, CD38_MACFA;  P56528, CD38_MOUSE;  
Q9MZ03, CD38_RABIT;  Q64244, CD38_RAT;  P29241, NADA_APLCA;  
Q27312, NADA_APLKU;  

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