ENZYME entry: EC 4.1.2.30
| Accepted Name |
|---|
| 17-alpha-hydroxyprogesterone aldolase.
|
| Alternative Name(s) |
|---|
| 17-alpha-hydroxyprogesterone acetaldehyde-lyase. |
| CYP17. |
| CYP17A1. |
| Reaction catalysed |
|---|
| 17-alpha-hydroxyprogesterone <=> androst-4-ene-3,17-dione + acetaldehyde |
| Comment(s) |
|---|
- A microsomal hemeprotein that catalyzes two independent reactions at
the same active site - the 17-hydroxylation of pregnenolone and
progesterone, which is part of glucocorticoid hormones biosynthesis
(EC 1.14.99.9), and the conversion of the 17-hydroxylated products
via a 17,20-lyase reaction to form androstenedione and
dehydroepiandrosterone, leading to sex hormone biosynthesis.
- The enzymes from different organisms differ in their substrate
specificity.
- While the enzymes from pig, hamster, and rat accept both 17-alpha-
hydroxyprogesterone and 17-alpha-hydroxypregnenolone, the enzymes
from human, bovine, sheep, goat, and bison do not accept the former,
and the enzyme from guinea pig does not accept the latter.
|
| Cross-references |
|---|
| BRENDA | 4.1.2.30 |
| EC2PDB | 4.1.2.30 |
| ExplorEnz | 4.1.2.30 |
| PRIAM enzyme-specific profiles | 4.1.2.30 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.2.30 |
| IUBMB Enzyme Nomenclature | 4.1.2.30 |
| IntEnz | 4.1.2.30 |
| MEDLINE | Find literature relating to 4.1.2.30 |
| MetaCyc | 4.1.2.30 |
| UniProtKB/Swiss-Prot |
| Q9GMC7, CP17A_BISBI; | P05185, CP17A_BOVIN; | Q9N0U7, CP17A_CAPHI; |
| Q64410, CP17A_CAVPO; | P12394, CP17A_CHICK; | Q9GMC8, CP17A_FELCA; |
| Q95328, CP17A_HORSE; | P05093, CP17A_HUMAN; | O73853, CP17A_ICTPU; |
| Q2XVA1, CP17A_MACFA; | Q8HYM9, CP17A_MACMU; | P70687, CP17A_MESAU; |
| P27786, CP17A_MOUSE; | P30437, CP17A_ONCMY; | P70085, CP17A_ORYLA; |
| Q8HYN1, CP17A_PANTR; | Q8HYN0, CP17A_PAPCY; | Q9GLD2, CP17A_PAPHU; |
| Q91Z85, CP17A_PERLE; | P19100, CP17A_PIG; | O57525, CP17A_RANDY; |
| P11715, CP17A_RAT; | Q29497, CP17A_SHEEP; | Q92113, CP17A_SQUAC; |
|
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