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ENZYME entry: EC 4.1.2.52

Accepted Name
4-hydroxy-2-oxoheptanedioate aldolase.
Alternative Name(s)
2,4-dihydroxyhept-2-enedioate aldolase.
4-hydroxy-2-ketoheptanedioate aldolase.
HHED aldolase.
HKHD aldolase.
Reaction catalysed
4-hydroxy-2-oxoheptanedioate <=> pyruvate + succinate semialdehyde
Cofactor(s)
Cobalt cation or Mn(2+).
Comment(s)
  • The enzyme is also able to catalyze the aldol cleavage of 4-hydroxy- 2-oxopentanoate and 4-hydroxy-2-oxohexanoate, and can use 2-oxobutanoate as carbonyl donor, with lower efficiency.
  • In the reverse direction, is able to condense a range of aldehyde acceptors with pyruvate.
  • The enzyme from the bacterium Escherichia coli produces a racemic mixture of (4R)- and (4S)-hydroxy-2-oxoheptanedioate.
  • Formerly EC 4.1.2.n4.
Cross-references
BRENDA4.1.2.52
EC2PDB4.1.2.52
ExplorEnz4.1.2.52
PRIAM enzyme-specific profiles4.1.2.52
KEGG Ligand Database for Enzyme Nomenclature4.1.2.52
IUBMB Enzyme Nomenclature4.1.2.52
IntEnz4.1.2.52
MEDLINEFind literature relating to 4.1.2.52
MetaCyc4.1.2.52
UniProtKB/Swiss-Prot
A8A876, HPCH_ECOHS;  B1IS70, HPCH_ECOLC;  Q47098, HPCH_ECOLX;  
B6I2N1, HPCH_ECOSE;  B5Y2D2, HPCH_KLEP3;  A6THU5, HPCH_KLEP7;  
B5F1Y9, HPCH_SALA4;  A9MH59, HPCH_SALAR;  Q57QP9, HPCH_SALCH;  
B5FR34, HPCH_SALDC;  Q9RPV0, HPCH_SALDU;  B5R043, HPCH_SALEP;  
B5R6F7, HPCH_SALG2;  B4TEM9, HPCH_SALHS;  B4T2T9, HPCH_SALNS;  
Q5PG96, HPCH_SALPA;  A9N6T0, HPCH_SALPB;  C0Q8A0, HPCH_SALPC;  
B5BBH8, HPCH_SALPK;  B4TSL7, HPCH_SALSV;  Q8Z7P9, HPCH_SALTI;  
Q8ZQ47, HPCH_SALTY;  B2TZN1, HPCH_SHIB3;  Q31SY8, HPCH_SHIBS;  
Q83P19, HPCH_SHIFL;  Q3YU43, HPCH_SHISS;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-