ENZYME entry: EC 4.1.3.17

Accepted Name
4-hydroxy-4-methyl-2-oxoglutarate aldolase.
Alternative Name(s)
4-carboxy-4-hydroxy-2-oxoadipate aldolase.
4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase.
CHA aldolase.
HMG aldolase.
Reaction catalysed
  • 4-hydroxy-4-methyl-2-oxoglutarate <=> 2 pyruvate
  • 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate <=> oxaloacetate + pyruvate
Cofactor(s)
Divalent cation.
Comment(s)
  • This enzyme participates in the degradation of protocatechuate (via the meta-cleavage pathway), phthalate, syringate and gallate.
  • The enzyme from Pseudomonas ochraceae can also cleave 4-hydroxy-2- oxoglutarate to glyoxylate and pyruvate, and also catalyzes the reaction of EC 4.1.1.3.
Cross-references
BRENDA4.1.3.17
EC2PDB4.1.3.17
ExplorEnz4.1.3.17
PRIAM enzyme-specific profiles4.1.3.17
KEGG Ligand Database for Enzyme Nomenclature4.1.3.17
IUBMB Enzyme Nomenclature4.1.3.17
IntEnz4.1.3.17
MEDLINEFind literature relating to 4.1.3.17
MetaCyc4.1.3.17
UniProtKB/Swiss-Prot
Q88JX9, GALC_PSEPK;  Q9AQI0, HMGA_PSEOC;  A5W059, HMGA_PSEP1;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.3.-
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