ENZYME entry: EC 4.1.99.14

Accepted Name
Spore photoproduct lyase.
Alternative Name(s)
SP lyase.
Reaction catalysed
(5R)-5,6-dihydro-5-(thymidin-7-yl)thymidine (in double-helical DNA) <=> thymidylyl-(3'->5')-thymidylate (in double-helical DNA)
Cofactor(s)
Iron-sulfur; S-adenosyl-L-methionine.
Comment(s)
  • This enzyme is a member of the 'AdoMet radical' (radical SAM) family.
  • The enzyme binds a [4Fe-4S] cluster.
  • The cluster is coordinated by 3 cysteines and an exchangeable SAM molecule.
  • The 5'-deoxy-adenosine radical formed after electron transfer from the [4Fe-4S] cluster to the S-adenosyl-L-methionine, initiates the repair by abstracting the C-6 hydrogen of the spore photoproduct lesion.
  • During the second part of the repair process the SAM molecule is regenerated.
Cross-references
BRENDA4.1.99.14
EC2PDB4.1.99.14
ExplorEnz4.1.99.14
PRIAM enzyme-specific profiles4.1.99.14
KEGG Ligand Database for Enzyme Nomenclature4.1.99.14
IUBMB Enzyme Nomenclature4.1.99.14
IntEnz4.1.99.14
MEDLINEFind literature relating to 4.1.99.14
MetaCyc4.1.99.14
UniProtKB/Swiss-Prot
Q97L63, SPLB_CLOAB;  P37956, SPL_BACSU;  C9RZ55, SPL_GEOSY;  

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