ENZYME entry: EC 4.1.99.19
| Accepted Name |
|---|
| 2-iminoacetate synthase.
|
| Reaction catalysed |
|---|
| L-tyrosine + S-adenosyl-L-methionine + reduced acceptor <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H(+) |
| Comment(s) |
|---|
- Binds a 4Fe-4S cluster that is coordinated by 3 cysteines and an
exchangeable S-adenosyl-L-methionine molecule.
- The first stage of catalysis is reduction of the S-adenosyl-L-
methionine to produce methionine and a 5-deoxyadenosin-5-yl radical
that is crucial for the conversion of the substrate.
- Part of the pathway for thiamine biosynthesis.
- Formerly EC 1.3.99.n2.
|
| Cross-references |
|---|
| BRENDA | 4.1.99.19 |
| EC2PDB | 4.1.99.19 |
| ExplorEnz | 4.1.99.19 |
| PRIAM enzyme-specific profiles | 4.1.99.19 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.99.19 |
| IUBMB Enzyme Nomenclature | 4.1.99.19 |
| IntEnz | 4.1.99.19 |
| MEDLINE | Find literature relating to 4.1.99.19 |
| MetaCyc | 4.1.99.19 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.1.99.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-