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ENZYME

ENZYME entry: EC 4.1.99.19

Accepted Name
2-iminoacetate synthase
Reaction catalysed
L-tyrosine + NADPH + S-adenosyl-L-methionine <=> 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP(+)
Comment(s)
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The first stage of catalysis is reduction of the S-adenosyl-L- methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate.
  • Part of the pathway for thiamine biosynthesis.
  • Formerly EC 1.3.99.n2.
Cross-references
BRENDA4.1.99.19
EC2PDB4.1.99.19
ExplorEnz4.1.99.19
PRIAM enzyme-specific profiles4.1.99.19
KEGG Ligand Database for Enzyme Nomenclature4.1.99.19
IUBMB Enzyme Nomenclature4.1.99.19
IntEnz4.1.99.19
MEDLINEFind literature relating to 4.1.99.19
MetaCyc4.1.99.19
Rhea expert-curated reactions4.1.99.19
UniProtKB/Swiss-Prot
P30140, THIH_ECOLIQ9S498, THIH_SALTY

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