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ENZYME entry: EC 188.8.131.52
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|UDP-N-acetylglucosamine 4,6-dehydratase (inverting).
|UDP-N-acetylglucosamine 5-inverting 4,6-dehydratase.|
|UDP-N-acetyl-alpha-D-glucosamine <=> UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H(2)O|
- The first enzyme in the biosynthetic pathway of pseudaminic acid,
a sialic-acid-like sugar that is unique to bacteria and is used by
Helicobacter pylori to modify its flagellin.
- Plays a critical role in H.pylori's pathogenesis, being involved in
the synthesis of both functional flagella and lipopolysaccharides.
- Completely inhibited by UDP-alpha-D-galactose.
- The reaction results in the chirality of the C-5 atom being inverted.
- It is thought that Lys-133 acts sequentially as a catalytic acid,
protonating the C-6 hydroxy group and as a catalytic base,
abstracting the C-5 proton, resulting in the elimination of water.
|PRIAM enzyme-specific profiles||184.108.40.206|
|KEGG Ligand Database for Enzyme Nomenclature||220.127.116.11|
|IUBMB Enzyme Nomenclature||18.104.22.168|
|MEDLINE||Find literature relating to 22.214.171.124|
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entries corresponding to 4.2.1.-
entries corresponding to 4.2.-.-
entries corresponding to 4.-.-.-