ENZYME entry: EC 4.2.1.136

Accepted Name
ADP-dependent NAD(P)H-hydrate dehydratase.
Alternative Name(s)
(6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolyzing; NADH-forming).
(6S)-beta-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolyzing).
Reaction catalysed
  • ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide <=> AMP + phosphate + NADH
  • ADP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine-dinucleotide phosphate <=> AMP + phosphate + NADPH
Comment(s)
  • Acts equally well on hydrated NADH and hydrated NADPH.
  • NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers.
  • The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (cf. EC 5.1.99.6), while the other catalyzes the dehydration.
  • Hence the enzyme can restore the complete mixture of isomers into NAD(P)H.
  • The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf. EC 4.2.1.93).
Cross-references
BRENDA4.2.1.136
EC2PDB4.2.1.136
ExplorEnz4.2.1.136
PRIAM enzyme-specific profiles4.2.1.136
KEGG Ligand Database for Enzyme Nomenclature4.2.1.136
IUBMB Enzyme Nomenclature4.2.1.136
IntEnz4.2.1.136
MEDLINEFind literature relating to 4.2.1.136
MetaCyc4.2.1.136
UniProtKB/Swiss-Prot
P94368, NNRD_BACSU;  Q7VU32, NNRD_BORPE;  A0RU82, NNRD_CENSY;  
Q833Y3, NNRD_ENTFA;  A6GXW4, NNRD_FLAPJ;  D2RXF6, NNRD_HALTV;  
Q9CIU7, NNRD_LACLA;  F9UN92, NNRD_LACPL;  Q8Y6R2, NNRD_LISMO;  
D3SQW0, NNRD_NATMM;  Q5F8G9, NNRD_NEIG1;  Q9JRZ9, NNRD_NEIMB;  
A9A498, NNRD_NITMS;  Q7UFW7, NNRD_RHOBA;  Q2G2P8, NNRD_STAA8;  
Q8DQD2, NNRD_STRR6;  P96051, NNRD_STRTR;  Q8PBP3, NNRD_XANCP;  
O67377, NNR_AQUAE;  O29407, NNR_ARCFU;  Q8NSS3, NNR_CORGL;  
Q83CM5, NNR_COXBU;  B8E2P6, NNR_DICTD;  P31806, NNR_ECOLI;  
Q7NIE6, NNR_GLOVI;  Q9ZJM4, NNR_HELPJ;  P56176, NNR_HELPY;  
A2BLC0, NNR_HYPBU;  B1L3W1, NNR_KORCO;  A4H7T9, NNR_LEIBR;  
A4HW65, NNR_LEIIN;  Q4QFL5, NNR_LEIMA;  Q2FT57, NNR_METHJ;  
Q58981, NNR_METJA;  Q8TX67, NNR_METKA;  O27324, NNR_METTH;  
Q2RGI2, NNR_MOOTA;  P37391, NNR_MYCLE;  P9WF10, NNR_MYCTO;  
P9WF11, NNR_MYCTU;  Q8ZV04, NNR_PYRAE;  Q2S580, NNR_SALRD;  
P74217, NNR_SYNY3;  D1BAA5, NNR_THEAS;  Q8DGC3, NNR_THEEB;  
Q9X024, NNR_THEMA;  A1S0R2, NNR_THEPD;  B5YIM0, NNR_THEYD;  
Q9KMX5, NNR_VIBCH;  

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