ENZYME entry: EC 4.2.1.78
| Accepted Name |
|---|
| (S)-norcoclaurine synthase.
|
| Alternative Name(s) |
|---|
| (S)-norlaudanosoline synthase. |
| Reaction catalysed |
|---|
| Dopamine + 4-hydroxyphenylacetaldehyde <=> (S)-norcoclaurine + H(2)O |
| Comment(s) |
|---|
- The reaction makes a 6-membered ring by forming a bond between C-6 of
the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde
in the imine formed between the substrates.
- The product is the precursor of the benzylisoquinoline alkaloids in
plants.
- Will also catalyze the reaction of 4-(2-aminoethyl)benzene-1,2-diol +
(3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline,
but this alkaloid has not been found to occur in plants.
|
| Cross-references |
|---|
| PROSITE | PDOC51471 |
| BRENDA | 4.2.1.78 |
| EC2PDB | 4.2.1.78 |
| ExplorEnz | 4.2.1.78 |
| PRIAM enzyme-specific profiles | 4.2.1.78 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.1.78 |
| IUBMB Enzyme Nomenclature | 4.2.1.78 |
| IntEnz | 4.2.1.78 |
| MEDLINE | Find literature relating to 4.2.1.78 |
| MetaCyc | 4.2.1.78 |
| UniProtKB/Swiss-Prot |
|
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