ENZYME entry: EC 4.2.1.78

Accepted Name
(S)-norcoclaurine synthase.
Alternative Name(s)
(S)-norlaudanosoline synthase.
Reaction catalysed
Dopamine + 4-hydroxyphenylacetaldehyde <=> (S)-norcoclaurine + H(2)O
Comment(s)
  • The reaction makes a 6-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates.
  • The product is the precursor of the benzylisoquinoline alkaloids in plants.
  • Will also catalyze the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants.
Cross-references
PROSITEPDOC51471
BRENDA4.2.1.78
EC2PDB4.2.1.78
ExplorEnz4.2.1.78
PRIAM enzyme-specific profiles4.2.1.78
KEGG Ligand Database for Enzyme Nomenclature4.2.1.78
IUBMB Enzyme Nomenclature4.2.1.78
IntEnz4.2.1.78
MEDLINEFind literature relating to 4.2.1.78
MetaCyc4.2.1.78
UniProtKB/Swiss-Prot
A2A1A0, NCS1_COPJA;  A2A1A1, NCS2_COPJA;  Q67A25, NCS_THLFG;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-