ENZYME entry: EC 4.2.2.11

Accepted Name
Guluronate-specific alginate lyase.
Alternative Name(s)
Alginase II.
Poly(alpha-L-guluronate) lyase.
Reaction catalysed
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at their reducing end
Comment(s)
  • The enzyme catalyzes the degradation of alginate by a beta- elimination reaction.
  • It cleaves the (1->4) bond between alpha-L-guluronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non- reducing ends and alpha-L-guluronate at the reducing end.
  • Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products.
  • Cf. EC 4.2.2.3.
Cross-references
BRENDA4.2.2.11
EC2PDB4.2.2.11
ExplorEnz4.2.2.11
PRIAM enzyme-specific profiles4.2.2.11
KEGG Ligand Database for Enzyme Nomenclature4.2.2.11
IUBMB Enzyme Nomenclature4.2.2.11
IntEnz4.2.2.11
MEDLINEFind literature relating to 4.2.2.11
MetaCyc4.2.2.11

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-