ENZYME entry: EC 4.2.3.24

Accepted Name
Amorpha-4,11-diene synthase.
Alternative Name(s)
Amorphadiene synthase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate <=> amorpha-4,11-diene + diphosphate
Cofactor(s)
Magnesium; Manganese.
Comment(s)
  • A key enzyme in the biosynthesis of the antimalarial endoperoxide artemisinin.
  • Catalyzes the formation of both olefinic and oxygenated sesquiterpenes, with amorpha-4,11-diene being the major product.
  • When geranyl diphosphate is used as a substrate, no monoterpenes are produced.
Cross-references
BRENDA4.2.3.24
EC2PDB4.2.3.24
ExplorEnz4.2.3.24
PRIAM enzyme-specific profiles4.2.3.24
KEGG Ligand Database for Enzyme Nomenclature4.2.3.24
IUBMB Enzyme Nomenclature4.2.3.24
IntEnz4.2.3.24
MEDLINEFind literature relating to 4.2.3.24
MetaCyc4.2.3.24
UniProtKB/Swiss-Prot
Q9AR04, AMS1_ARTAN

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
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