ENZYME entry: EC 4.99.1.4

Accepted Name
Sirohydrochlorin ferrochelatase.
Reaction catalysed
Siroheme + 2 H(+) <=> sirohydrochlorin + Fe(2+)
Comment(s)
  • This enzyme catalyzes the third of three steps leading to the formation of siroheme from uroporphyrinogen III.
  • The first step involves the donation of two S-adenosyl-L-methionine- derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to form precorrin-2 (EC 2.1.1.107) and the second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76).
  • In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.
  • In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirB being responsible for the above reaction.
Cross-references
BRENDA4.99.1.4
EC2PDB4.99.1.4
ExplorEnz4.99.1.4
PRIAM enzyme-specific profiles4.99.1.4
KEGG Ligand Database for Enzyme Nomenclature4.99.1.4
IUBMB Enzyme Nomenclature4.99.1.4
IntEnz4.99.1.4
MEDLINEFind literature relating to 4.99.1.4
MetaCyc4.99.1.4
UniProtKB/Swiss-Prot
Q72CB8, CBIKC_DESVH;  Q72EC8, CBIKP_DESVH;  A0KLD7, CYSG1_AERHH;  
A4SHL4, CYSG1_AERS4;  A7MJ67, CYSG1_CROS8;  A1WWP8, CYSG1_HALHL;  
A6TD45, CYSG1_KLEP7;  Q6D1A4, CYSG1_PECAS;  A8G9Y3, CYSG1_SERP5;  
A1JJS8, CYSG1_YERE8;  A7FLY4, CYSG1_YERP3;  Q1CLS2, CYSG1_YERPN;  
A4TGU8, CYSG1_YERPP;  Q66EC9, CYSG1_YERPS;  A0KP37, CYSG2_AERHH;  
A4SRH0, CYSG2_AERS4;  A7MKK9, CYSG2_CROS8;  A1WYD5, CYSG2_HALHL;  
A6TF07, CYSG2_KLEP7;  Q6CZS0, CYSG2_PECAS;  A8GKQ1, CYSG2_SERP5;  
A1JSB7, CYSG2_YERE8;  A7FNS9, CYSG2_YERP3;  Q1CCP6, CYSG2_YERPN;  
A4TPZ1, CYSG2_YERPP;  Q664M6, CYSG2_YERPS;  A0KQJ4, CYSG3_AERHH;  
Q6F8G6, CYSG_ACIAD;  B3GZA0, CYSG_ACTP7;  B0BTC2, CYSG_ACTPJ;  
A6VPZ6, CYSG_ACTSZ;  Q0VQ05, CYSG_ALCBS;  Q0A812, CYSG_ALKEH;  
C1DKY7, CYSG_AZOVD;  Q1LTP4, CYSG_BAUCH;  Q7VQG9, CYSG_BLOFL;  
Q493N1, CYSG_BLOPB;  Q2KWB0, CYSG_BORA1;  Q7WMM4, CYSG_BORBR;  
Q7WB57, CYSG_BORPA;  A9HZV6, CYSG_BORPD;  Q7VZ77, CYSG_BORPE;  
P57500, CYSG_BUCAI;  Q7NZV7, CYSG_CHRVO;  A8AQS4, CYSG_CITK8;  
A7ZSP4, CYSG_ECO24;  B7UK79, CYSG_ECO27;  B7MCY5, CYSG_ECO45;  
B7L4P2, CYSG_ECO55;  P0AEA9, CYSG_ECO57;  B5YTS6, CYSG_ECO5E;  
B7NMD7, CYSG_ECO7I;  B7N1F1, CYSG_ECO81;  B7M1S1, CYSG_ECO8A;  
C4ZUM4, CYSG_ECOBW;  B1X716, CYSG_ECODH;  A8A5H5, CYSG_ECOHS;  
A1AGQ2, CYSG_ECOK1;  Q0TC92, CYSG_ECOL5;  Q8FCW8, CYSG_ECOL6;  
B1IP96, CYSG_ECOLC;  P0AEA8, CYSG_ECOLI;  B7NDX8, CYSG_ECOLU;  
B6I2S7, CYSG_ECOSE;  B1LHG9, CYSG_ECOSM;  Q1R5R3, CYSG_ECOUT;  
C5BGP8, CYSG_EDWI9;  A4WFH1, CYSG_ENT38;  B7LS75, CYSG_ESCF3;  
A9H259, CYSG_GLUDA;  Q5FP95, CYSG_GLUOX;  Q2SJB7, CYSG_HAHCH;  
Q65T49, CYSG_MANSM;  Q606C9, CYSG_METCA;  Q1H3L5, CYSG_METFK;  
A9LZ77, CYSG_NEIM0;  P57001, CYSG_NEIMA;  P95370, CYSG_NEIMB;  
A1KU10, CYSG_NEIMF;  Q0AHC1, CYSG_NITEC;  Q820Q4, CYSG_NITEU;  
Q2Y6L7, CYSG_NITMU;  Q3JCS0, CYSG_NITOC;  Q7N8L2, CYSG_PHOLL;  
Q6LM67, CYSG_PHOPR;  Q48H75, CYSG_PSE14;  Q15YU1, CYSG_PSEA6;  
A6V4H6, CYSG_PSEA7;  B7UW11, CYSG_PSEA8;  Q02NA3, CYSG_PSEAB;  
Q9I0M7, CYSG_PSEAE;  Q1IBC9, CYSG_PSEE4;  Q4K9V8, CYSG_PSEF5;  
C3JY53, CYSG_PSEFS;  Q3ILQ9, CYSG_PSEHT;  A4XUX3, CYSG_PSEMY;  
A5W1H7, CYSG_PSEP1;  Q3KA85, CYSG_PSEPF;  Q88FT3, CYSG_PSEPK;  
B1JBD9, CYSG_PSEPW;  Q87ZT0, CYSG_PSESM;  Q4ZRL6, CYSG_PSEU2;  
A4VLU6, CYSG_PSEU5;  Q4FSU1, CYSG_PSYA2;  Q1QAX7, CYSG_PSYCK;  
A1SRP9, CYSG_PSYIN;  A5WEG6, CYSG_PSYWF;  A1AVU5, CYSG_RUTMC;  
Q21K21, CYSG_SACD2;  B5F8J0, CYSG_SALA4;  A9MME5, CYSG_SALAR;  
Q57IZ5, CYSG_SALCH;  B5FJQ1, CYSG_SALDC;  B5R2C7, CYSG_SALEP;  
B5R7N6, CYSG_SALG2;  B4TKQ4, CYSG_SALHS;  B4SVI1, CYSG_SALNS;  
Q5PLV8, CYSG_SALPA;  A9MT45, CYSG_SALPB;  C0Q0F3, CYSG_SALPC;  
B5BH22, CYSG_SALPK;  B4TY38, CYSG_SALSV;  Q8Z201, CYSG_SALTI;  
P25924, CYSG_SALTY;  B2U3H4, CYSG_SHIB3;  Q31VS0, CYSG_SHIBS;  
Q32AZ8, CYSG_SHIDS;  Q0SZU8, CYSG_SHIF8;  Q83JB3, CYSG_SHIFL;  
Q3YWQ3, CYSG_SHISS;  Q2NVN0, CYSG_SODGM;  Q31GG8, CYSG_THICR;  
Q3SG32, CYSG_THIDA;  B8GUD3, CYSG_THISH;  C4LAG5, CYSG_TOLAT;  
A5CXE4, CYSG_VESOH;  B2I985, CYSG_XYLF2;  Q9PF46, CYSG_XYLFA;  
B0U4X0, CYSG_XYLFM;  Q87AI5, CYSG_XYLFT;  Q1C2P9, CYSG_YERPA;  
Q74Y23, CYSG_YERPE;  Q5NRM4, CYSG_ZYMMO;  O14172, MET8_SCHPO;  
P15807, MET8_YEAST;  P61817, SIRB_BACME;  O34632, SIRB_BACSU;  

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