ENZYME entry: EC 2.1.1.107

Accepted Name
Uroporphyrinogen-III C-methyltransferase.
Alternative Name(s)
Adenosylmethionine-uroporphyrinogen III methyltransferase.
S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase.
SUMT.
Urogen III methylase.
Uroporphyrin-III C-methyltransferase.
Uroporphyrinogen III methylase.
Uroporphyrinogen methyltransferase.
Uroporphyrinogen-III methylase.
Uroporphyrinogen-III methyltransferase.
Reaction catalysed
  • S-adenosyl-L-methionine + uroporphyrinogen III <=> S-adenosyl-L-homocysteine + precorrin-1
  • S-adenosyl-L-methionine + precorrin-1 <=> S-adenosyl-L-homocysteine + precorrin-2
Comment(s)
  • This enzyme catalyzes two sequential methylation reactions, the first forming precorrin-1 and the second leading to the formation of precorrin-2.
  • It is the first of three steps leading to the formation of siroheme from uroporphyrinogen III.
  • The second step involves an NAD(+)-dependent dehydrogenation to form sirohydrochlorin from precorrin-2 (EC 1.3.1.76) and the third step involves the chelation of Fe(2+) to sirohydrochlorin to form siroheme (EC 4.99.1.4).
  • In Saccharomyces cerevisiae, the last two steps are carried out by a single bifunctional enzyme, Met8p.
  • In some bacteria, steps 1-3 are catalyzed by a single multifunctional protein called CysG, whereas in Bacillus megaterium, three separate enzymes carry out each of the steps, with SirA being responsible for the above reaction.
  • Also involved in the biosynthesis of cobalamin.
Cross-references
PROSITEPDOC00656
BRENDA2.1.1.107
EC2PDB2.1.1.107
ExplorEnz2.1.1.107
PRIAM enzyme-specific profiles2.1.1.107
KEGG Ligand Database for Enzyme Nomenclature2.1.1.107
IUBMB Enzyme Nomenclature2.1.1.107
IntEnz2.1.1.107
MEDLINEFind literature relating to 2.1.1.107
MetaCyc2.1.1.107
UniProtKB/Swiss-Prot
A0KLD7, CYSG1_AERHH;  A4SHL4, CYSG1_AERS4;  A7MJ67, CYSG1_CROS8;  
A1WWP8, CYSG1_HALHL;  A6TD45, CYSG1_KLEP7;  Q6D1A4, CYSG1_PECAS;  
A8G9Y3, CYSG1_SERP5;  A1JJS8, CYSG1_YERE8;  A7FLY4, CYSG1_YERP3;  
Q1CLS2, CYSG1_YERPN;  A4TGU8, CYSG1_YERPP;  Q66EC9, CYSG1_YERPS;  
A0KP37, CYSG2_AERHH;  A4SRH0, CYSG2_AERS4;  A7MKK9, CYSG2_CROS8;  
A1WYD5, CYSG2_HALHL;  A6TF07, CYSG2_KLEP7;  Q6CZS0, CYSG2_PECAS;  
A8GKQ1, CYSG2_SERP5;  A1JSB7, CYSG2_YERE8;  A7FNS9, CYSG2_YERP3;  
Q1CCP6, CYSG2_YERPN;  A4TPZ1, CYSG2_YERPP;  Q664M6, CYSG2_YERPS;  
A0KQJ4, CYSG3_AERHH;  Q6F8G6, CYSG_ACIAD;  B3GZA0, CYSG_ACTP7;  
B0BTC2, CYSG_ACTPJ;  A6VPZ6, CYSG_ACTSZ;  Q0VQ05, CYSG_ALCBS;  
Q0A812, CYSG_ALKEH;  C1DKY7, CYSG_AZOVD;  Q1LTP4, CYSG_BAUCH;  
Q7VQG9, CYSG_BLOFL;  Q493N1, CYSG_BLOPB;  Q2KWB0, CYSG_BORA1;  
Q7WMM4, CYSG_BORBR;  Q7WB57, CYSG_BORPA;  A9HZV6, CYSG_BORPD;  
Q7VZ77, CYSG_BORPE;  P57500, CYSG_BUCAI;  Q7NZV7, CYSG_CHRVO;  
A8AQS4, CYSG_CITK8;  A7ZSP4, CYSG_ECO24;  B7UK79, CYSG_ECO27;  
B7MCY5, CYSG_ECO45;  B7L4P2, CYSG_ECO55;  P0AEA9, CYSG_ECO57;  
B5YTS6, CYSG_ECO5E;  B7NMD7, CYSG_ECO7I;  B7N1F1, CYSG_ECO81;  
B7M1S1, CYSG_ECO8A;  C4ZUM4, CYSG_ECOBW;  B1X716, CYSG_ECODH;  
A8A5H5, CYSG_ECOHS;  A1AGQ2, CYSG_ECOK1;  Q0TC92, CYSG_ECOL5;  
Q8FCW8, CYSG_ECOL6;  B1IP96, CYSG_ECOLC;  P0AEA8, CYSG_ECOLI;  
B7NDX8, CYSG_ECOLU;  B6I2S7, CYSG_ECOSE;  B1LHG9, CYSG_ECOSM;  
Q1R5R3, CYSG_ECOUT;  C5BGP8, CYSG_EDWI9;  A4WFH1, CYSG_ENT38;  
B7LS75, CYSG_ESCF3;  A9H259, CYSG_GLUDA;  Q5FP95, CYSG_GLUOX;  
Q2SJB7, CYSG_HAHCH;  Q65T49, CYSG_MANSM;  Q606C9, CYSG_METCA;  
Q1H3L5, CYSG_METFK;  A9LZ77, CYSG_NEIM0;  P57001, CYSG_NEIMA;  
P95370, CYSG_NEIMB;  A1KU10, CYSG_NEIMF;  Q0AHC1, CYSG_NITEC;  
Q820Q4, CYSG_NITEU;  Q2Y6L7, CYSG_NITMU;  Q3JCS0, CYSG_NITOC;  
Q7N8L2, CYSG_PHOLL;  Q6LM67, CYSG_PHOPR;  Q48H75, CYSG_PSE14;  
Q15YU1, CYSG_PSEA6;  A6V4H6, CYSG_PSEA7;  B7UW11, CYSG_PSEA8;  
Q02NA3, CYSG_PSEAB;  Q9I0M7, CYSG_PSEAE;  Q1IBC9, CYSG_PSEE4;  
Q4K9V8, CYSG_PSEF5;  C3JY53, CYSG_PSEFS;  Q3ILQ9, CYSG_PSEHT;  
A4XUX3, CYSG_PSEMY;  A5W1H7, CYSG_PSEP1;  Q3KA85, CYSG_PSEPF;  
Q88FT3, CYSG_PSEPK;  B1JBD9, CYSG_PSEPW;  Q87ZT0, CYSG_PSESM;  
Q4ZRL6, CYSG_PSEU2;  A4VLU6, CYSG_PSEU5;  Q4FSU1, CYSG_PSYA2;  
Q1QAX7, CYSG_PSYCK;  A1SRP9, CYSG_PSYIN;  A5WEG6, CYSG_PSYWF;  
A1AVU5, CYSG_RUTMC;  Q21K21, CYSG_SACD2;  B5F8J0, CYSG_SALA4;  
A9MME5, CYSG_SALAR;  Q57IZ5, CYSG_SALCH;  B5FJQ1, CYSG_SALDC;  
B5R2C7, CYSG_SALEP;  B5R7N6, CYSG_SALG2;  B4TKQ4, CYSG_SALHS;  
B4SVI1, CYSG_SALNS;  Q5PLV8, CYSG_SALPA;  A9MT45, CYSG_SALPB;  
C0Q0F3, CYSG_SALPC;  B5BH22, CYSG_SALPK;  B4TY38, CYSG_SALSV;  
Q8Z201, CYSG_SALTI;  P25924, CYSG_SALTY;  B2U3H4, CYSG_SHIB3;  
Q31VS0, CYSG_SHIBS;  Q32AZ8, CYSG_SHIDS;  Q0SZU8, CYSG_SHIF8;  
Q83JB3, CYSG_SHIFL;  Q3YWQ3, CYSG_SHISS;  Q2NVN0, CYSG_SODGM;  
Q31GG8, CYSG_THICR;  Q3SG32, CYSG_THIDA;  B8GUD3, CYSG_THISH;  
C4LAG5, CYSG_TOLAT;  A5CXE4, CYSG_VESOH;  B2I985, CYSG_XYLF2;  
Q9PF46, CYSG_XYLFA;  B0U4X0, CYSG_XYLFM;  Q87AI5, CYSG_XYLFT;  
Q1C2P9, CYSG_YERPA;  Q74Y23, CYSG_YERPE;  Q5NRM4, CYSG_ZYMMO;  
Q59294, HEM4_CLOJO;  P09127, HEMX_ECOLI;  Q51887, HEMX_PROMI;  
P42437, NASF_BACSU;  Q51701, NIRE_PARDP;  P29928, SUMT_BACME;  
O34744, SUMT_BACSU;  O19889, SUMT_CYACA;  P29564, SUMT_METIV;  
Q58375, SUMT_METJA;  Q9I2W4, SUMT_PSEAE;  P21631, SUMT_PSEDE;  
P37725, SUMT_PSEFL;  O74468, SUMT_SCHPO;  P42451, SUMT_SYNE7;  
Q55749, SUMT_SYNY3;  P36150, SUMT_YEAST;  

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