ENZYME entry: EC 5.4.2.11

Accepted Name
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent).
Alternative Name(s)
2,3-diphosphoglycerate dependent phosphoglycerate mutase.
Cofactor dependent phosphoglycerate mutase.
PGAM.
Phosphoglycerate phosphomutase.
Phosphoglyceromutase.
Reaction catalysed
2-phospho-D-glycerate <=> 3-phospho-D-glycerate
Comment(s)
  • The enzymes from vertebrates, platyhelminths, mollusks, annelids, crustaceans, insects, algae, fungi, yeast and some bacteria (particularly Gram-negative) require 2,3-bisphospho-D-glycerate as a cofactor.
  • The enzyme is activated by 2,3-bisphospho-D-glycerate by transferring a phosphate to histidine (His(10) in man and Escherichia coli, His(8) in Saccharomyces cerevisiae).
  • This phosphate can be transferred to the free OH of 2-phospho-D- glycerate, followed by transfer of the phosphate already on the phosphoglycerate back to the histidine.
  • Cf. EC 5.4.2.12.
  • The enzyme has no requirement for metal ions.
  • This enzyme also catalyze, slowly, the reactions of EC 5.4.2.4.
  • Formerly EC 2.7.5.3 and EC 5.4.2.1.
Cross-references
PROSITEPDOC00158
BRENDA5.4.2.11
EC2PDB5.4.2.11
ExplorEnz5.4.2.11
PRIAM enzyme-specific profiles5.4.2.11
KEGG Ligand Database for Enzyme Nomenclature5.4.2.11
IUBMB Enzyme Nomenclature5.4.2.11
IntEnz5.4.2.11
MEDLINEFind literature relating to 5.4.2.11
MetaCyc5.4.2.11
UniProtKB/Swiss-Prot
Q737X5, GPMA1_BACC1;  Q8A8R2, GPMA1_BACTN;  Q7NK82, GPMA1_GLOVI;  
Q74LL9, GPMA1_LACJO;  Q88YY8, GPMA1_LACPL;  Q38ZH8, GPMA1_LACSS;  
Q82XS4, GPMA1_NITEU;  Q2YBZ1, GPMA1_NITMU;  Q732Z5, GPMA2_BACC1;  
Q8A765, GPMA2_BACTN;  Q7NJF7, GPMA2_GLOVI;  Q74L45, GPMA2_LACJO;  
Q88T35, GPMA2_LACPL;  Q38Z74, GPMA2_LACSS;  Q82TU0, GPMA2_NITEU;  
Q2Y9Z7, GPMA2_NITMU;  A1TTW5, GPMA_ACIAC;  B9MEZ2, GPMA_ACIET;  
A1WBJ3, GPMA_ACISJ;  A3N0J2, GPMA_ACTP2;  B3H1G9, GPMA_ACTP7;  
B0BPB3, GPMA_ACTPJ;  A6VLV0, GPMA_ACTSZ;  B9J6R3, GPMA_AGRRK;  
B9JYQ2, GPMA_AGRVS;  Q0A915, GPMA_ALKEH;  B4RZM6, GPMA_ALTMD;  
Q5P7N4, GPMA_AROAE;  A0JSU9, GPMA_ARTS2;  A8IGZ9, GPMA_AZOC5;  
A1K9B9, GPMA_AZOSB;  C3PAW8, GPMA_BACAA;  C3LIE5, GPMA_BACAC;  
A0RE96, GPMA_BACAH;  Q6KSL4, GPMA_BACAN;  B7JPK2, GPMA_BACC0;  
B7IX37, GPMA_BACC2;  C1EUQ5, GPMA_BACC3;  B7H7P4, GPMA_BACC4;  
B7HS46, GPMA_BACC7;  A7GPN5, GPMA_BACCN;  B9J102, GPMA_BACCQ;  
Q81DD2, GPMA_BACCR;  Q63B92, GPMA_BACCZ;  Q5LAT7, GPMA_BACFN;  
Q64R85, GPMA_BACFR;  Q6HIL9, GPMA_BACHK;  A9VFW9, GPMA_BACWK;  
A1UTM4, GPMA_BARBK;  Q8L1Z7, GPMA_BARHE;  Q6FZ12, GPMA_BARQU;  
A9IXE7, GPMA_BART1;  Q1LTL3, GPMA_BAUCH;  Q6MJP3, GPMA_BDEBA;  
B2IEV6, GPMA_BEII9;  B3DQI6, GPMA_BIFLD;  P59159, GPMA_BIFLO;  
B7GUR7, GPMA_BIFLS;  Q7VR80, GPMA_BLOFL;  Q492W5, GPMA_BLOPB;  
Q2L0A6, GPMA_BORA1;  Q0SMJ5, GPMA_BORAP;  Q660L2, GPMA_BORBP;  
Q7WQN2, GPMA_BORBR;  O51602, GPMA_BORBU;  B7J2L3, GPMA_BORBZ;  
B5RMK4, GPMA_BORDL;  B2S101, GPMA_BORHD;  Q7W1Q6, GPMA_BORPA;  
A9IFJ0, GPMA_BORPD;  Q7VS43, GPMA_BORPE;  B5RQ00, GPMA_BORRA;  
A1R083, GPMA_BORT9;  Q89WK1, GPMA_BRADU;  C0QV47, GPMA_BRAHW;  
A5E8K1, GPMA_BRASB;  A4YJP8, GPMA_BRASO;  B2SC37, GPMA_BRUA1;  
Q2YJN6, GPMA_BRUA2;  Q576R3, GPMA_BRUAB;  A9MCX8, GPMA_BRUC2;  
C0RMJ1, GPMA_BRUMB;  Q8YDC9, GPMA_BRUME;  A5VVV5, GPMA_BRUO2;  
A9WW62, GPMA_BRUSI;  P59160, GPMA_BRUSU;  B8D995, GPMA_BUCA5;  
P57390, GPMA_BUCAI;  Q8K9N1, GPMA_BUCAP;  B8D7J7, GPMA_BUCAT;  
Q89AJ4, GPMA_BUCBP;  Q057P1, GPMA_BUCCC;  B1YNA6, GPMA_BURA4;  
B1JZ61, GPMA_BURCC;  B4EA64, GPMA_BURCJ;  Q0BBK5, GPMA_BURCM;  
Q39CN6, GPMA_BURL3;  A3MQ23, GPMA_BURM7;  A2S625, GPMA_BURM9;  
Q62F43, GPMA_BURMA;  A1UZX9, GPMA_BURMS;  A3NR09, GPMA_BURP0;  
Q3JWH7, GPMA_BURP1;  A3N5B0, GPMA_BURP6;  Q63XU7, GPMA_BURPS;  
Q2T1H5, GPMA_BURTA;  A4JI45, GPMA_BURVG;  Q8R7C8, GPMA_CALS4;  
B8GYN6, GPMA_CAUCN;  Q9A634, GPMA_CAUCR;  B0SY17, GPMA_CAUSK;  
Q11CB5, GPMA_CHESB;  Q5L4Y3, GPMA_CHLAB;  Q3AU60, GPMA_CHLCH;  
Q821N6, GPMA_CHLCV;  Q256A6, GPMA_CHLFF;  B3EFK8, GPMA_CHLL2;  
Q3B5J2, GPMA_CHLL7;  Q9PLK4, GPMA_CHLMU;  B3QPN8, GPMA_CHLP8;  
B3EN99, GPMA_CHLPB;  A1BE55, GPMA_CHLPD;  A4SDM0, GPMA_CHLPM;  
Q9Z743, GPMA_CHLPN;  B0B8U8, GPMA_CHLT2;  B3QVL0, GPMA_CHLT3;  
Q3KKX2, GPMA_CHLTA;  B0BAH7, GPMA_CHLTB;  Q8KFC8, GPMA_CHLTE;  
O84727, GPMA_CHLTR;  A8AJ40, GPMA_CITK8;  A5CTZ0, GPMA_CLAM3;  
B0RAW4, GPMA_CLAMS;  Q97FJ6, GPMA_CLOAB;  A6LUA1, GPMA_CLOB8;  
A9KN01, GPMA_CLOPH;  B5Y7Q7, GPMA_COPPD;  Q6NJL2, GPMA_CORDI;  
Q8FSH0, GPMA_COREF;  A4QB41, GPMA_CORGB;  Q8NTA5, GPMA_CORGL;  
Q4JSW4, GPMA_CORJK;  C4LLD4, GPMA_CORK4;  A7MIX7, GPMA_CROS8;  
Q0KET8, GPMA_CUPNH;  Q476J7, GPMA_CUPPJ;  B2AGP7, GPMA_CUPTR;  
B7KIT8, GPMA_CYAP7;  Q11SV1, GPMA_CYTH3;  A9BUZ3, GPMA_DELAS;  
Q30WZ8, GPMA_DESAG;  C4XIQ5, GPMA_DESMR;  Q727C0, GPMA_DESVH;  
B8DLN4, GPMA_DESVM;  A1VAI9, GPMA_DESVV;  A5EV29, GPMA_DICNV;  
A7ZJD0, GPMA_ECO24;  B7ULM8, GPMA_ECO27;  B7MGL2, GPMA_ECO45;  
B7LAF6, GPMA_ECO55;  P62709, GPMA_ECO57;  B5YRF2, GPMA_ECO5E;  
B7NNH7, GPMA_ECO7I;  B7MPN9, GPMA_ECO81;  B7M6B8, GPMA_ECO8A;  
C4ZXS6, GPMA_ECOBW;  B1X786, GPMA_ECODH;  A7ZY11, GPMA_ECOHS;  
A1A8Z8, GPMA_ECOK1;  Q0TJU6, GPMA_ECOL5;  P62708, GPMA_ECOL6;  
B1IXY1, GPMA_ECOLC;  P62707, GPMA_ECOLI;  B7N9Z7, GPMA_ECOLU;  
B6I7Q9, GPMA_ECOSE;  B1LM46, GPMA_ECOSM;  C5BEL3, GPMA_EDWI9;  
B2KBU4, GPMA_ELUMP;  A4W897, GPMA_ENT38;  Q839H4, GPMA_ENTFA;  
B2VBS6, GPMA_ERWT9;  Q2N682, GPMA_ERYLH;  B7LK04, GPMA_ESCF3;  
Q0RS35, GPMA_FRAAA;  Q8RFG9, GPMA_FUSNN;  B5EC38, GPMA_GEOBB;  
Q39V40, GPMA_GEOMG;  Q74CR0, GPMA_GEOSL;  C6E639, GPMA_GEOSM;  
Q7VL28, GPMA_HAEDU;  Q4QME2, GPMA_HAEI8;  A5UDW8, GPMA_HAEIE;  
A5UHR1, GPMA_HAEIG;  P44865, GPMA_HAEIN;  B8F5J4, GPMA_HAEPS;  
Q0I4D8, GPMA_HAES1;  A1WWH7, GPMA_HALHL;  C4K389, GPMA_HAMD5;  
B0US27, GPMA_HISS2;  B4U616, GPMA_HYDS0;  Q0C678, GPMA_HYPNA;  
B5XZB2, GPMA_KLEP3;  A6T6I3, GPMA_KLEP7;  Q5FMJ3, GPMA_LACAC;  
Q9CIM0, GPMA_LACLA;  A2RI67, GPMA_LACLM;  Q031Y3, GPMA_LACLS;  
Q6ADH3, GPMA_LEIXX;  B1Y3R5, GPMA_LEPCP;  Q929G8, GPMA_LISIN;  
C1KXG0, GPMA_LISMC;  Q71XG0, GPMA_LISMF;  B8DFA5, GPMA_LISMH;  
Q8Y571, GPMA_LISMO;  A0AKV8, GPMA_LISW6;  Q65Q32, GPMA_MANSM;  
Q0ALQ9, GPMA_MARMM;  Q8TN93, GPMA_METAC;  A7I8A7, GPMA_METB6;  
B7KNX9, GPMA_METC4;  A9W5P5, GPMA_METEP;  Q2FTH0, GPMA_METHJ;  
B3DZZ7, GPMA_METI4;  Q8PST3, GPMA_METMA;  B1ZA86, GPMA_METPB;  
B8GFF8, GPMA_METPE;  A2SDN6, GPMA_METPP;  B1M6A7, GPMA_METRJ;  
B0UBD4, GPMA_METS4;  B8EML2, GPMA_METSB;  A6US15, GPMA_METVS;  
A0QLK3, GPMA_MYCA1;  P0A5R7, GPMA_MYCBO;  A1KFW3, GPMA_MYCBP;  
C1AKG7, GPMA_MYCBT;  B8ZT86, GPMA_MYCLB;  P53531, GPMA_MYCLE;  
B2HQV4, GPMA_MYCMM;  Q73SU2, GPMA_MYCPA;  A5TZL7, GPMA_MYCTA;  
P9WIC8, GPMA_MYCTO;  P9WIC9, GPMA_MYCTU;  A0PVZ3, GPMA_MYCUA;  
B9L9H5, GPMA_NAUPA;  Q5F7C0, GPMA_NEIG1;  B4RIY7, GPMA_NEIG2;  
A9M1A2, GPMA_NEIM0;  Q9JTF2, GPMA_NEIMA;  Q9JYF7, GPMA_NEIMB;  
A1KV25, GPMA_NEIMF;  Q1QRT7, GPMA_NITHX;  Q3JBA8, GPMA_NITOC;  
Q3SW71, GPMA_NITWN;  Q5YP50, GPMA_NOCFA;  A1SP05, GPMA_NOCSJ;  
Q2G373, GPMA_NOVAD;  A6WYJ2, GPMA_OCHA4;  B6JCI9, GPMA_OLICO;  
A6L9K8, GPMA_PARD8;  A7HZ35, GPMA_PARL1;  B2JC95, GPMA_PARP8;  
B2SX15, GPMA_PARPJ;  Q6MEW4, GPMA_PARUW;  Q9CKU9, GPMA_PASMU;  
Q6D7E3, GPMA_PECAS;  C6DCF6, GPMA_PECCP;  B4SEI0, GPMA_PELPB;  
Q4FP74, GPMA_PELUB;  Q7N6S0, GPMA_PHOLL;  A1VKR6, GPMA_POLNA;  
B1XS92, GPMA_POLNS;  A4T096, GPMA_POLSQ;  B2RHB7, GPMA_PORG3;  
Q7MXP1, GPMA_PORGI;  B4S616, GPMA_PROA2;  Q6AAU8, GPMA_PROAC;  
B4EST0, GPMA_PROMH;  Q15SN0, GPMA_PSEA6;  B8HCQ9, GPMA_PSECP;  
Q8Y2I3, GPMA_RALSO;  B3PXK3, GPMA_RHIE6;  Q8KL44, GPMA_RHIEC;  
Q1MMY4, GPMA_RHIL3;  Q98DM0, GPMA_RHILO;  B5ZWT2, GPMA_RHILW;  
Q92T25, GPMA_RHIME;  B6IYD3, GPMA_RHOCS;  Q21YW0, GPMA_RHOFT;  
Q0SF09, GPMA_RHOJR;  C1AZ61, GPMA_RHOOB;  Q07UT3, GPMA_RHOP5;  
Q21CH5, GPMA_RHOPB;  B5F050, GPMA_SALA4;  Q57RI5, GPMA_SALCH;  
B5FP39, GPMA_SALDC;  B5QX43, GPMA_SALEP;  B5R739, GPMA_SALG2;  
B4TC26, GPMA_SALHS;  B4SZH5, GPMA_SALNS;  Q5PG75, GPMA_SALPA;  
A9MTL3, GPMA_SALPB;  C0PWW0, GPMA_SALPC;  B5BC52, GPMA_SALPK;  
B4TQR7, GPMA_SALSV;  Q8Z8B2, GPMA_SALTI;  Q8ZQS2, GPMA_SALTY;  
A8GBA2, GPMA_SERP5;  B2TUY6, GPMA_SHIB3;  Q324G4, GPMA_SHIBS;  
Q32IH0, GPMA_SHIDS;  Q0T6Y5, GPMA_SHIF8;  P62710, GPMA_SHIFL;  
Q3Z455, GPMA_SHISS;  C3MBY8, GPMA_SINFN;  A6UEW3, GPMA_SINMW;  
Q2NUK6, GPMA_SODGM;  Q01YD0, GPMA_SOLUE;  Q1GP88, GPMA_SPHAL;  
A5VB15, GPMA_SPHWW;  A7X656, GPMA_STAA1;  A6U4E6, GPMA_STAA2;  
Q2FE81, GPMA_STAA3;  Q2FVK8, GPMA_STAA8;  A5IVJ6, GPMA_STAA9;  
Q2YVZ6, GPMA_STAAB;  Q5HDD9, GPMA_STAAC;  A6QJQ5, GPMA_STAAE;  
P65708, GPMA_STAAM;  P99153, GPMA_STAAN;  Q6GE17, GPMA_STAAR;  
Q6G6Q5, GPMA_STAAS;  A8YYG4, GPMA_STAAT;  P65709, GPMA_STAAW;  
B9DL85, GPMA_STACT;  Q5HLI0, GPMA_STAEQ;  Q8CN61, GPMA_STAES;  
Q4L8T0, GPMA_STAHJ;  Q49ZZ2, GPMA_STAS1;  Q3K1U2, GPMA_STRA1;  
Q8E643, GPMA_STRA3;  Q8E0G9, GPMA_STRA5;  Q82GB8, GPMA_STRAW;  
P33158, GPMA_STRCO;  C0M8R8, GPMA_STRE4;  B4U1Y5, GPMA_STREM;  
A8AW46, GPMA_STRGC;  B1VS80, GPMA_STRGG;  B4SPL6, GPMA_STRM5;  
B2FHH6, GPMA_STRMK;  P59161, GPMA_STRMU;  Q99Z29, GPMA_STRP1;  
Q04JB4, GPMA_STRP2;  P0DD06, GPMA_STRP3;  B5E706, GPMA_STRP4;  
Q5XB88, GPMA_STRP6;  C1C8P5, GPMA_STRP7;  P65711, GPMA_STRP8;  
Q1JAX0, GPMA_STRPB;  Q1JL20, GPMA_STRPC;  Q1JG44, GPMA_STRPD;  
Q1J5W1, GPMA_STRPF;  A2RDV4, GPMA_STRPG;  B1I720, GPMA_STRPI;  
B8ZM52, GPMA_STRPJ;  Q48SP2, GPMA_STRPM;  P0A3Y3, GPMA_STRPN;  
P0DD07, GPMA_STRPQ;  B2IRR1, GPMA_STRPS;  B5XM69, GPMA_STRPZ;  
P0A3Y4, GPMA_STRR6;  A4W369, GPMA_STRS2;  C0MCW5, GPMA_STRS7;  
A3CLS0, GPMA_STRSV;  Q5LZF1, GPMA_STRT1;  Q8VVB5, GPMA_STRT2;  
Q03KA9, GPMA_STRTD;  B9DUS6, GPMA_STRU0;  C1CFM7, GPMA_STRZJ;  
C1CLZ5, GPMA_STRZP;  C1CSS1, GPMA_STRZT;  C5BJ25, GPMA_TERTT;  
Q47KS8, GPMA_THEFY;  B0KBW9, GPMA_THEP3;  B0K4E2, GPMA_THEPX;  
Q73M14, GPMA_TREDE;  P96121, GPMA_TREPA;  B2S2B5, GPMA_TREPS;  
Q83HD5, GPMA_TROW8;  Q83FQ7, GPMA_TROWT;  B1GZZ1, GPMA_UNCTG;  
C5CWV9, GPMA_VARPS;  A1WDX2, GPMA_VEREI;  Q8D2Y4, GPMA_WIGBR;  
Q8PIM1, GPMA_XANAC;  Q3BR53, GPMA_XANC5;  Q4UWV1, GPMA_XANC8;  
B0RQR7, GPMA_XANCB;  Q8P7A1, GPMA_XANCP;  Q2P5R0, GPMA_XANOM;  
B2SRM8, GPMA_XANOP;  Q5H2V7, GPMA_XANOR;  A7IC75, GPMA_XANP2;  
B2I4U0, GPMA_XYLF2;  Q9PC88, GPMA_XYLFA;  B0U2F2, GPMA_XYLFM;  
Q87CZ1, GPMA_XYLFT;  A1JRT1, GPMA_YERE8;  A7FKP6, GPMA_YERP3;  
Q1C964, GPMA_YERPA;  B2K8R3, GPMA_YERPB;  Q8ZGY5, GPMA_YERPE;  
A9R3B3, GPMA_YERPG;  Q1CFN6, GPMA_YERPN;  A4TNS2, GPMA_YERPP;  
Q66D83, GPMA_YERPS;  B1JSU1, GPMA_YERPY;  P30798, GPMA_ZYMMO;  
Q9HIJ2, GPM_THEAC;  Q3SZ62, PGAM1_BOVIN;  Q5ZLN1, PGAM1_CHICK;  
P18669, PGAM1_HUMAN;  Q9DBJ1, PGAM1_MOUSE;  Q5RFB8, PGAM1_PONAB;  
P25113, PGAM1_RAT;  Q32KV0, PGAM2_BOVIN;  P15259, PGAM2_HUMAN;  
O70250, PGAM2_MOUSE;  P16290, PGAM2_RAT;  Q8N0Y7, PGAM4_HUMAN;  
Q8MKE8, PGAM4_PANTR;  Q54NE6, PGAM_DICDI;  P00950, PMG1_YEAST;  
Q12008, PMG2_YEAST;  Q12326, PMG3_YEAST;  Q3T014, PMGE_BOVIN;  
P07738, PMGE_HUMAN;  Q4R6L7, PMGE_MACFA;  P15327, PMGE_MOUSE;  
P07952, PMGE_RABIT;  P82612, PMGY_CANAL;  P36623, PMGY_SCHPO;  

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