ENZYME entry: EC 6.5.1.6

Accepted Name
DNA ligase (ATP or NAD(+)).
Reaction catalysed
  • ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) <=> AMP + diphosphate + (deoxyribonucleotide)(n+m)
  • NAD(+) + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) <=> AMP + beta-nicotinamide D-ribonucleotide + (deoxyribonucleotide)(n+m)
Comment(s)
  • The enzymes from the archaea Thermococcus fumicolans and Thermococcus onnurineus show high activity with either ATP or NAD(+), and significantly lower activity with TTP, GTP, and CTP.
  • Different from EC 6.5.1.1, EC 6.5.1.2 and EC 6.5.1.7.
Cross-references
BRENDA6.5.1.6
EC2PDB6.5.1.6
ExplorEnz6.5.1.6
PRIAM enzyme-specific profiles6.5.1.6
KEGG Ligand Database for Enzyme Nomenclature6.5.1.6
IUBMB Enzyme Nomenclature6.5.1.6
IntEnz6.5.1.6
MEDLINEFind literature relating to 6.5.1.6
MetaCyc6.5.1.6
UniProtKB/Swiss-Prot
Q9HH07, DNLI_THEFM;  Q9HHC4, DNLI_THEKO;  B6YTR4, DNLI_THEON;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-