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ENZYME entry: EC 6.5.1.7

Accepted Name
DNA ligase (ATP, ADP or GTP).
Reaction catalysed
  • ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) <=> AMP + diphosphate + (deoxyribonucleotide)(n+m)
  • ADP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) <=> AMP + phosphate + (deoxyribonucleotide)(n+m)
  • GTP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) <=> GMP + diphosphate + (deoxyribonucleotide)(n+m)
Comment(s)
  • The enzymes from the archaea Hyperthermus butylicus and Sulfophobococcus zilligii are active with ATP, ADP or GTP.
  • They show no activity with NAD(+).
  • Different from EC 6.5.1.1, which is specific for ATP, and EC 6.5.1.6, which can utilize either ATP or NAD(+).
Cross-references
BRENDA6.5.1.7
EC2PDB6.5.1.7
ExplorEnz6.5.1.7
PRIAM enzyme-specific profiles6.5.1.7
KEGG Ligand Database for Enzyme Nomenclature6.5.1.7
IUBMB Enzyme Nomenclature6.5.1.7
IntEnz6.5.1.7
MEDLINEFind literature relating to 6.5.1.7
MetaCyc6.5.1.7
UniProtKB/Swiss-Prot
A2BJX6, DNLI_HYPBU;  D2CJS7, DNLI_SULZI;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-