ENZYME entry: EC 1.1.1.206
Accepted Name |
Tropinone reductase I.
|
Alternative Name(s) |
TR-I. |
Tropine dehydrogenase. |
Tropinone reductase. |
Reaction catalysed |
Tropine + NADP(+) <=> tropinone + NADPH |
Comment(s) |
- Also oxidizes other tropan-3-alpha-ols, but not the corresponding
beta-derivatives.
- Represents, along with EC 1.1.1.236, a branch point in tropane
alkaloid metabolism.
- Tropine (the product of EC 1.1.1.206) is incorporated into
hyoscyamine and scopolamine whereas pseudotropine (the product of
EC 1.1.1.236) is the first specific metabolite on the pathway to the
calystegines.
- Both enzymes are always found together in any given tropane-alkaloid-
producing species, have a common substrate, tropinone, and are
strictly stereospecific.
|
Cross-references |
PROSITE | PDOC00060 |
BRENDA | 1.1.1.206 |
EC2PDB | 1.1.1.206 |
ExplorEnz | 1.1.1.206 |
PRIAM enzyme-specific profiles | 1.1.1.206 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.206 |
IUBMB Enzyme Nomenclature | 1.1.1.206 |
IntEnz | 1.1.1.206 |
MEDLINE | Find literature relating to 1.1.1.206 |
MetaCyc | 1.1.1.206 |
Rhea expert-curated reactions | 1.1.1.206 |
UniProtKB/Swiss-Prot |
|
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