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ENZYME entry: EC 1.1.1.206

Accepted Name
Tropinone reductase I.
Alternative Name(s)
TR-I.
Tropine dehydrogenase.
Tropinone reductase.
Reaction catalysed
Tropine + NADP(+) <=> tropinone + NADPH
Comment(s)
  • Also oxidizes other tropan-3-alpha-ols, but not the corresponding beta-derivatives.
  • Represents, along with EC 1.1.1.236, a branch point in tropane alkaloid metabolism.
  • Tropine (the product of EC 1.1.1.206) is incorporated into hyoscyamine and scopolamine whereas pseudotropine (the product of EC 1.1.1.236) is the first specific metabolite on the pathway to the calystegines.
  • Both enzymes are always found together in any given tropane-alkaloid- producing species, have a common substrate, tropinone, and are strictly stereospecific.
Cross-references
PROSITEPDOC00060
BRENDA1.1.1.206
EC2PDB1.1.1.206
ExplorEnz1.1.1.206
PRIAM enzyme-specific profiles1.1.1.206
KEGG Ligand Database for Enzyme Nomenclature1.1.1.206
IUBMB Enzyme Nomenclature1.1.1.206
IntEnz1.1.1.206
MEDLINEFind literature relating to 1.1.1.206
MetaCyc1.1.1.206
Rhea expert-curated reactions1.1.1.206
UniProtKB/Swiss-Prot
A7DY56, TRN1_COCOF;  P50162, TRN1_DATST;  

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