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ENZYME

ENZYME entry: EC 1.1.1.270

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.270
Accepted Name
3beta-hydroxysteroid 3-dehydrogenase
Alternative Name(s)
3-keto-steroid reductase
3-KSR
Reaction catalysed
a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH + H(+)
Comment(s)
  • The enzyme acts on multiple 3beta-hydroxysteroids.
  • Participates in the biosynthesis of zemosterol and cholesterol, where it catalyzes the reaction in the opposite direction to that shown.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.62.
Cross-references
BRENDA1.1.1.270
EC2PDB1.1.1.270
ExplorEnz1.1.1.270
KEGG Ligand Database for Enzyme Nomenclature1.1.1.270
IUBMB Enzyme Nomenclature1.1.1.270
MEDLINEFind literature relating to 1.1.1.270
MetaCyc1.1.1.270
Rhea expert-curated reactions1.1.1.270
UniProtKB/Swiss-Prot
P14060, 3BHS1_HUMANP27365, 3BHS1_MACMUQ60555, 3BHS1_MESAU
P24815, 3BHS1_MOUSEP22071, 3BHS1_RATO35296, 3BHS3_MESAU
Q61767, 3BHS4_MOUSEQ61694, 3BHS5_MOUSEP27364, 3BHS5_RAT
Q04828, AK1C1_HUMANQ95JH7, AK1C1_MACFAQ95JH6, AK1C1_MACFU
Q5REQ0, AK1C1_PONABP56937, DHB7_HUMANO88736, DHB7_MOUSE
Q62904, DHB7_RATQ3ZBV9, DHR11_BOVINQ71R50, DHR11_CHICK
Q6UWP2, DHR11_HUMANQ3U0B3, DHR11_MOUSEQ5A888, ERG27_CANAL
Q874K0, ERG27_CANAXQ6FIV3, ERG27_CANGAQ6BNP0, ERG27_DEBHA
Q74ZZ0, ERG27_EREGSQ6CJC2, ERG27_KLULAO74732, ERG27_SCHPO
Q6CE88, ERG27_YARLIQ12452, ERG27_YEASTQ60A54, SDMB_METCA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
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