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ENZYME

ENZYME entry: EC 1.1.1.62

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.62
Accepted Name
17beta-estradiol 17-dehydrogenase
Alternative Name(s)
17beta-estradiol dehydrogenase
17beta-HSD
17beta-hydroxysteroid dehydrogenase
20alpha-hydroxysteroid dehydrogenase
estrogen 17-oxidoreductase
Reaction catalysed
  • 17beta-estradiol + NAD(+) = estrone + NADH + H(+)
  • 17beta-estradiol + NADP(+) = estrone + NADPH + H(+)
Comment(s)
  • The enzyme oxidizes or reduces the hydroxy/keto group on C17 of estrogens and androgens in mammals and regulates the biological potency of these steroids.
  • The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270.
  • The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
Cross-references
BRENDA1.1.1.62
EC2PDB1.1.1.62
ExplorEnz1.1.1.62
KEGG Ligand Database for Enzyme Nomenclature1.1.1.62
IUBMB Enzyme Nomenclature1.1.1.62
MEDLINEFind literature relating to 1.1.1.62
MetaCyc1.1.1.62
Rhea expert-curated reactions1.1.1.62
UniProtKB/Swiss-Prot
Q04828, AK1C1_HUMANQ95JH7, AK1C1_MACFAQ95JH6, AK1C1_MACFU
Q5REQ0, AK1C1_PONABP52895, AK1C2_HUMANP05980, AK1C3_BOVIN
P42330, AK1C3_HUMANQ5R7C9, AK1C3_PONABP52898, AK1C4_BOVIN
P17516, AK1C4_HUMANQ95JH5, AK1C4_MACFAQ95JH4, AK1C4_MACFU
Q6P3L6, DH12A_DANREQ5XG41, DH12A_XENLAQ6QA33, DH12B_DANRE
Q8AVY8, DH12B_XENLAQ8NBQ5, DHB11_HUMANQ4JK73, DHB11_MACFA
Q9EQ06, DHB11_MOUSEQ5NVG2, DHB11_PONABQ6AYS8, DHB11_RAT
O57314, DHB12_ANAPLQ5E9H7, DHB12_BOVINQ53GQ0, DHB12_HUMAN
Q4R5G7, DHB12_MACFAO70503, DHB12_MOUSEQ6P7R8, DHB12_RAT
Q28IU1, DHB12_XENTRQ7Z5P4, DHB13_HUMANQ8VCR2, DHB13_MOUSE
Q5M875, DHB13_RATP14061, DHB1_HUMANP51656, DHB1_MOUSE
Q1WNP0, DHB1_PANTRP51657, DHB1_RATP37059, DHB2_HUMAN
P51658, DHB2_MOUSEQ62730, DHB2_RATP37058, DHB3_HUMAN
P70385, DHB3_MOUSEO54939, DHB3_RATP56937, DHB7_HUMAN
O88736, DHB7_MOUSEQ62904, DHB7_RATQ9GME3, DHB8_CALJA
Q5TJF5, DHB8_CANLFQ92506, DHB8_HUMANP50171, DHB8_MOUSE
Q9XT00, DHB8_PIGQ6MGB5, DHB8_RATQ3ZBV9, DHR11_BOVIN
Q71R50, DHR11_CHICKQ6UWP2, DHR11_HUMANQ3U0B3, DHR11_MOUSE
Q3T001, H17B6_BOVINO14756, H17B6_HUMANQ9R092, H17B6_MOUSE
O54753, H17B6_RATO02691, HCD2_BOVINO18404, HCD2_DROME
Q99714, HCD2_HUMANO08756, HCD2_MOUSEO70351, HCD2_RAT
Q93W57, HSDA_SESINQ8LKV5, HSDB_SESINA0A140FAN3, HSD_PINMS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-