ENZYME entry: EC 1.1.1.272
| Accepted Name |
|---|
| D-2-hydroxyacid dehydrogenase (NADP(+)).
|
| Reaction catalysed |
|---|
| An (R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + NADPH |
| Comment(s) |
|---|
- This enzyme, characterized from the halophilic archaeon Haloferax
mediterranei and the mold Aspergillus oryzae, catalyzes a reversible
stereospecific reduction of 2-oxocarboxylic acids into the
corresponding D-2-hydroxycarboxylic acids.
- The enzyme prefers substrates with a main chain of 5 carbons (such as
4-methyl-2-oxopentanoate) to those with a shorter chain, and can use
NADH with much lower efficiency.
- cf. EC 1.1.1.345.
|
| Cross-references |
|---|
| BRENDA | 1.1.1.272 |
| EC2PDB | 1.1.1.272 |
| ExplorEnz | 1.1.1.272 |
| PRIAM enzyme-specific profiles | 1.1.1.272 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.272 |
| IUBMB Enzyme Nomenclature | 1.1.1.272 |
| IntEnz | 1.1.1.272 |
| MEDLINE | Find literature relating to 1.1.1.272 |
| MetaCyc | 1.1.1.272 |
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