ENZYME entry: EC 1.1.1.272
Accepted Name |
D-2-hydroxyacid dehydrogenase (NADP(+)).
|
Reaction catalysed |
An (R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + NADPH |
Comment(s) |
- This enzyme, characterized from the halophilic archaeon Haloferax
mediterranei and the mold Aspergillus oryzae, catalyzes a reversible
stereospecific reduction of 2-oxocarboxylic acids into the
corresponding D-2-hydroxycarboxylic acids.
- The enzyme prefers substrates with a main chain of 5 carbons (such as
4-methyl-2-oxopentanoate) to those with a shorter chain, and can use
NADH with much lower efficiency.
- cf. EC 1.1.1.345.
|
Cross-references |
BRENDA | 1.1.1.272 |
EC2PDB | 1.1.1.272 |
ExplorEnz | 1.1.1.272 |
PRIAM enzyme-specific profiles | 1.1.1.272 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.272 |
IUBMB Enzyme Nomenclature | 1.1.1.272 |
IntEnz | 1.1.1.272 |
MEDLINE | Find literature relating to 1.1.1.272 |
MetaCyc | 1.1.1.272 |
Rhea expert-curated reactions | 1.1.1.272 |
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UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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