Expasy logo

ENZYME

ENZYME entry: EC 1.1.1.272

Accepted Name
D-2-hydroxyacid dehydrogenase (NADP(+))
Reaction catalysed
a (2R)-2-hydroxycarboxylate + NADP(+) = a 2-oxocarboxylate + H(+) + NADPH
Comment(s)
  • This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyzes a reversible stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids.
  • The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency. cf. EC 1.1.1.345.
Cross-references
BRENDA1.1.1.272
EC2PDB1.1.1.272
ExplorEnz1.1.1.272
PRIAM enzyme-specific profiles1.1.1.272
KEGG Ligand Database for Enzyme Nomenclature1.1.1.272
IUBMB Enzyme Nomenclature1.1.1.272
IntEnz1.1.1.272
MEDLINEFind literature relating to 1.1.1.272
MetaCyc1.1.1.272
Rhea expert-curated reactions1.1.1.272
UniProtKB/Swiss-Prot
Q2UH56, HADHA_ASPORQ2U0N3, MORA_ASPOR

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-