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ENZYME entry: EC 1.1.1.272

Accepted Name
D-2-hydroxyacid dehydrogenase (NADP(+)).
Reaction catalysed
a (2R)-2-hydroxycarboxylate + NADP(+) <=> a 2-oxocarboxylate + H(+) + NADPH
Comment(s)
  • This enzyme, characterized from the halophilic archaeon Haloferax mediterranei and the mold Aspergillus oryzae, catalyzes a reversible stereospecific reduction of 2-oxocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids.
  • The enzyme prefers substrates with a main chain of 5 carbons (such as 4-methyl-2-oxopentanoate) to those with a shorter chain, and can use NADH with much lower efficiency.
  • cf. EC 1.1.1.345.
Cross-references
BRENDA1.1.1.272
EC2PDB1.1.1.272
ExplorEnz1.1.1.272
PRIAM enzyme-specific profiles1.1.1.272
KEGG Ligand Database for Enzyme Nomenclature1.1.1.272
IUBMB Enzyme Nomenclature1.1.1.272
IntEnz1.1.1.272
MEDLINEFind literature relating to 1.1.1.272
MetaCyc1.1.1.272
Rhea expert-curated reactions1.1.1.272
UniProtKB/Swiss-Prot
Q2UH56, HADHA_ASPOR;  Q2U0N3, MORA_ASPOR;  

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