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ENZYME

ENZYME entry: EC 1.1.1.345

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.345
Accepted Name
D-2-hydroxyacid dehydrogenase (NAD(+))
Alternative Name(s)
(R)-2-hydroxyisocaproate dehydrogenase
D-2-hydroxyisocaproate dehydrogenase
Reaction catalysed
a (2R)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + NADH + H(+)
Comment(s)
  • The enzymes, characterized from bacteria (Peptoclostridium difficile, Enterococcus faecalis and from lactic acid bacteria) prefer substrates with a main chain of 5 carbons (such as 4-methyl-2- oxopentanoate) to those with a shorter chain.
  • It also utilizes phenylpyruvate.
  • The enzyme from the halophilic archaeon Haloferax mediterranei prefers substrates with a main chain of 3-4 carbons (pyruvate and 2-oxobutanoate). cf. EC 1.1.1.272.
Cross-references
BRENDA1.1.1.345
EC2PDB1.1.1.345
ExplorEnz1.1.1.345
KEGG Ligand Database for Enzyme Nomenclature1.1.1.345
IUBMB Enzyme Nomenclature1.1.1.345
MEDLINEFind literature relating to 1.1.1.345
MetaCyc1.1.1.345
Rhea expert-curated reactions1.1.1.345
UniProtKB/Swiss-Prot
P17584, DHD2_LACPAQ5U922, LDHA_CLODIQ05709, VANH_ENTFC

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