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ENZYME entry: EC 1.1.1.345

Accepted Name
D-2-hydroxyacid dehydrogenase (NAD(+)).
Alternative Name(s)
(R)-2-hydroxyisocaproate dehydrogenase.
D-2-hydroxyisocaproate dehydrogenase.
Reaction catalysed
An (R)-2-hydroxcarboxylate + NAD(+) <=> a 2-oxocarboxylate + NADH
Comment(s)
  • The enzymes, characterized from bacteria (Peptoclostridium difficile, Enterococcus faecalis and from lactic acid bacteria) prefer substrates with a main chain of 5 carbons (such as 4-methyl-2- oxopentanoate) to those with a shorter chain.
  • It also utilizes phenylpyruvate.
  • The enzyme from the halophilic archaeon Haloferax mediterranei prefers substrates with a main chain of 3-4 carbons (pyruvate and 2-oxobutanoate).
  • Cf. EC 1.1.1.272.
Cross-references
BRENDA1.1.1.345
EC2PDB1.1.1.345
ExplorEnz1.1.1.345
PRIAM enzyme-specific profiles1.1.1.345
KEGG Ligand Database for Enzyme Nomenclature1.1.1.345
IUBMB Enzyme Nomenclature1.1.1.345
IntEnz1.1.1.345
MEDLINEFind literature relating to 1.1.1.345
MetaCyc1.1.1.345
Rhea expert-curated reactions1.1.1.345

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