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ENZYME

ENZYME entry: EC 1.1.1.300

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.300
Accepted Name
NADP-retinol dehydrogenase
Alternative Name(s)
all-trans retinal reductase
all-trans-retinol dehydrogenase
NADP(H)-dependent retinol dehydrogenase/reductase
retinol dehydrogenase [NADP(+)]
Reaction catalysed
all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)
Comment(s)
  • Greater catalytic efficiency in the reductive direction.
  • This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63.
  • Km-values for NADP(+) and NADPH are at least 800-fold lower than those for NAD(+) and NADH.
  • This enzyme differs from EC 1.1.1.105 which prefers NAD(+) and NADH.
  • Formerly EC 1.1.1.n2.
Cross-references
BRENDA1.1.1.300
EC2PDB1.1.1.300
ExplorEnz1.1.1.300
KEGG Ligand Database for Enzyme Nomenclature1.1.1.300
IUBMB Enzyme Nomenclature1.1.1.300
MEDLINEFind literature relating to 1.1.1.300
MetaCyc1.1.1.300
Rhea expert-curated reactions1.1.1.300
UniProtKB/Swiss-Prot
O60218, AK1BA_HUMANC9JRZ8, AK1BF_HUMANP16116, ALDR_BOVIN
M9PF61, ALDR_DROMEP15121, ALDR_HUMANP45376, ALDR_MOUSE
P80276, ALDR_PIGP15122, ALDR_RABITP07943, ALDR_RAT
O77769, DHRS3_BOVINO75911, DHRS3_HUMANO88876, DHRS3_MOUSE
Q8SPU8, DHRS4_BOVINQ99LB2, DHRS4_MOUSEQ8WNV7, DHRS4_PIG
Q9GKX2, DHRS4_RABITQ8VID1, DHRS4_RATA1L1W4, RD10A_DANRE
Q6DCT3, RD10A_XENLAQ7T2D1, RD10B_DANREQ6NRV4, RD10B_XENLA
Q8HZT6, RDH10_BOVINQ8IZV5, RDH10_HUMANQ8VCH7, RDH10_MOUSE
Q80ZF7, RDH10_RATQ5XGF7, RDH10_XENTRQ8TC12, RDH11_HUMAN
Q9QYF1, RDH11_MOUSEP59837, RDH12_BOVINQ96NR8, RDH12_HUMAN
Q8BYK4, RDH12_MOUSEQ8NBN7, RDH13_HUMANQ8CEE7, RDH13_MOUSE
Q17QW3, RDH14_BOVINQ9HBH5, RDH14_HUMANQ9ERI6, RDH14_MOUSE
Q9N126, RDH8_BOVINQ9NYR8, RDH8_HUMAN

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