| Accepted Name |
|---|
| NADP-retinol dehydrogenase.
|
| Alternative Name(s) |
|---|
| All-trans retinal reductase. |
| All-trans-retinol dehydrogenase. |
| NADP(H)-dependent retinol dehydrogenase/reductase. |
| Retinol dehydrogenase (NADP(+)). |
| Reaction catalysed |
|---|
| All-trans-retinol + NADP(+) <=> all-trans-retinal + NADPH |
| Comment(s) |
|---|
- Greater catalytic efficiency in the reductive direction.
- This observation, and the enzyme's localization at the entrance to
the mitochondrial matrix, suggest that it may function to protect
mitochondria against oxidative stress associated with the highly
reactive retinal produced from dietary beta-carotene by
EC 1.13.11.63.
- Km-values for NADP(+) and NADPH are at least 800-fold lower than
those for NAD(+) and NADH.
- This enzyme differs from EC 1.1.1.105 which prefers NAD(+) and NADH.
- Formerly EC 1.1.1.n2.
|
| Cross-references |
|---|
| PROSITE | PDOC00060 |
| BRENDA | 1.1.1.300 |
| EC2PDB | 1.1.1.300 |
| ExplorEnz | 1.1.1.300 |
| PRIAM enzyme-specific profiles | 1.1.1.300 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.300 |
| IUBMB Enzyme Nomenclature | 1.1.1.300 |
| IntEnz | 1.1.1.300 |
| MEDLINE | Find literature relating to 1.1.1.300 |
| MetaCyc | 1.1.1.300 |
| Rhea expert-curated reactions | 1.1.1.300 |
| UniProtKB/Swiss-Prot |
| O60218, AK1BA_HUMAN; | C9JRZ8, AK1BF_HUMAN; | P16116, ALDR_BOVIN; |
| P15121, ALDR_HUMAN; | P45376, ALDR_MOUSE; | P80276, ALDR_PIG; |
| P15122, ALDR_RABIT; | P07943, ALDR_RAT; | O77769, DHRS3_BOVIN; |
| O75911, DHRS3_HUMAN; | O88876, DHRS3_MOUSE; | Q8SPU8, DHRS4_BOVIN; |
| Q99LB2, DHRS4_MOUSE; | Q8WNV7, DHRS4_PIG; | Q9GKX2, DHRS4_RABIT; |
| Q8VID1, DHRS4_RAT; | A1L1W4, RD10A_DANRE; | Q6DCT3, RD10A_XENLA; |
| Q7T2D1, RD10B_DANRE; | Q6NRV4, RD10B_XENLA; | Q8HZT6, RDH10_BOVIN; |
| Q8IZV5, RDH10_HUMAN; | Q8VCH7, RDH10_MOUSE; | Q80ZF7, RDH10_RAT; |
| Q5XGF7, RDH10_XENTR; | Q8TC12, RDH11_HUMAN; | Q9QYF1, RDH11_MOUSE; |
| P59837, RDH12_BOVIN; | Q96NR8, RDH12_HUMAN; | Q8BYK4, RDH12_MOUSE; |
| Q8NBN7, RDH13_HUMAN; | Q8CEE7, RDH13_MOUSE; | Q17QW3, RDH14_BOVIN; |
| Q9HBH5, RDH14_HUMAN; | Q9ERI6, RDH14_MOUSE; | Q9N126, RDH8_BOVIN; |
| Q9NYR8, RDH8_HUMAN; |
|