Expasy logo

ENZYME

ENZYME entry: EC 1.1.1.300

Accepted Name
NADP-retinol dehydrogenase
Alternative Name(s)
all-trans retinal reductase
all-trans-retinol dehydrogenase
NADP(H)-dependent retinol dehydrogenase/reductase
retinol dehydrogenase [NADP(+)]
Reaction catalysed
all-trans-retinol + NADP(+) <=> all-trans-retinal + H(+) + NADPH
Comment(s)
  • Greater catalytic efficiency in the reductive direction.
  • This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63.
  • Km-values for NADP(+) and NADPH are at least 800-fold lower than those for NAD(+) and NADH.
  • This enzyme differs from EC 1.1.1.105 which prefers NAD(+) and NADH.
  • Formerly EC 1.1.1.n2.
Cross-references
BRENDA1.1.1.300
EC2PDB1.1.1.300
ExplorEnz1.1.1.300
PRIAM enzyme-specific profiles1.1.1.300
KEGG Ligand Database for Enzyme Nomenclature1.1.1.300
IUBMB Enzyme Nomenclature1.1.1.300
IntEnz1.1.1.300
MEDLINEFind literature relating to 1.1.1.300
MetaCyc1.1.1.300
Rhea expert-curated reactions1.1.1.300
UniProtKB/Swiss-Prot
O60218, AK1BA_HUMANC9JRZ8, AK1BF_HUMANP16116, ALDR_BOVIN
P15121, ALDR_HUMANP45376, ALDR_MOUSEP80276, ALDR_PIG
P15122, ALDR_RABITP07943, ALDR_RATO77769, DHRS3_BOVIN
O75911, DHRS3_HUMANO88876, DHRS3_MOUSEQ8SPU8, DHRS4_BOVIN
Q99LB2, DHRS4_MOUSEQ8WNV7, DHRS4_PIGQ9GKX2, DHRS4_RABIT
Q8VID1, DHRS4_RATA1L1W4, RD10A_DANREQ6DCT3, RD10A_XENLA
Q7T2D1, RD10B_DANREQ6NRV4, RD10B_XENLAQ8HZT6, RDH10_BOVIN
Q8IZV5, RDH10_HUMANQ8VCH7, RDH10_MOUSEQ80ZF7, RDH10_RAT
Q5XGF7, RDH10_XENTRQ8TC12, RDH11_HUMANQ9QYF1, RDH11_MOUSE
P59837, RDH12_BOVINQ96NR8, RDH12_HUMANQ8BYK4, RDH12_MOUSE
Q8NBN7, RDH13_HUMANQ8CEE7, RDH13_MOUSEQ17QW3, RDH14_BOVIN
Q9HBH5, RDH14_HUMANQ9ERI6, RDH14_MOUSEQ9N126, RDH8_BOVIN
Q9NYR8, RDH8_HUMAN

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-