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ENZYME

ENZYME entry: EC 1.1.1.307

Accepted Name
D-xylose reductase [NAD(P)H]
Alternative Name(s)
D-xylose reductase
xylose reductase
Reaction catalysed
  • NAD(+) + xylitol <=> D-xylose + H(+) + NADH
  • NADP(+) + xylitol <=> D-xylose + H(+) + NADPH
Comment(s)
  • Xylose reductases catalyze the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway.
  • Most of the enzymes exhibit a strict requirement for NADPH (cf. EC 1.1.1.431).
  • However, a few D-xylose reductases, such as those from Neurospora crassa, Yamadazyma tenuis, Scheffersomyces stipitis, and the thermophilic fungus Chaetomium thermophilum, have dual coenzyme specificity, though they still prefer NADPH to NADH.
  • Very rarely the enzyme prefers NADH (cf. EC 1.1.1.430).
Cross-references
BRENDA1.1.1.307
EC2PDB1.1.1.307
ExplorEnz1.1.1.307
PRIAM enzyme-specific profiles1.1.1.307
KEGG Ligand Database for Enzyme Nomenclature1.1.1.307
IUBMB Enzyme Nomenclature1.1.1.307
IntEnz1.1.1.307
MEDLINEFind literature relating to 1.1.1.307
MetaCyc1.1.1.307
Rhea expert-curated reactions1.1.1.307
UniProtKB/Swiss-Prot
C5FFQ7, XYL1_ARTOCA1CRI1, XYL1_ASPCLB0XNR0, XYL1_ASPFC
B8N195, XYL1_ASPFNQ4WJT9, XYL1_ASPFUA2Q8B5, XYL1_ASPNC
Q9P8R5, XYL1_ASPNGQ2UKD0, XYL1_ASPORQ0CUL0, XYL1_ASPTN
Q8X195, XYL1_CANBOQ6Y0Z3, XYL1_CANPAO74237, XYL1_CANTE
O13283, XYL1_CANTRQ5BGA7, XYL1_EMENIP49378, XYL1_KLULC
G4N708, XYL1_MAGO7A1D4E3, XYL1_NEOFIP78736, XYL1_PACTA
O94735, XYL1_PICGUP31867, XYL1_PICSTQ9P430, XYL1_SCHSH
P87039, XYL2_CANTR

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