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ENZYME

ENZYME entry: EC 1.1.1.430

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.430
Accepted Name
D-xylose reductase (NADH)
Reaction catalysed
xylitol + NAD(+) = D-xylose + NADH + H(+)
Comment(s)
  • Xylose reductases catalyze the reduction of xylose to xylitol, the initial reaction in the fungal D-xylose degradation pathway.
  • Most of the enzymes exhibit a strict requirement for NADPH (cf. EC 1.1.1.431).
  • Some D-xylose reductases have dual cofactor specificity, though they still prefer NADPH to NADH (cf. EC 1.1.1.307).
  • The enzyme from Candida parapsilosis is a rare example of a xylose reductase that significantly prefers NADH, with Km and Vmax values for NADH being 10-fold lower and 10-fold higher, respectively, than for NADPH.
Cross-references
Rhea expert-curated reactions1.1.1.430
ExplorEnz1.1.1.430
IUBMB Enzyme Nomenclature1.1.1.430
UniProtKB/Swiss-Prot
P38715, GRE3_YEASTC5FFQ7, XYL1_ARTOCA1CRI1, XYL1_ASPCL
A1D4E3, XYL1_ASPF1B0XNR0, XYL1_ASPFCB8N195, XYL1_ASPFN
Q4WJT9, XYL1_ASPFUA2Q8B5, XYL1_ASPNCQ9P8R5, XYL1_ASPNG
Q2UKD0, XYL1_ASPORQ0CUL0, XYL1_ASPTNQ8X195, XYL1_CANBO
Q6Y0Z3, XYL1_CANPAO74237, XYL1_CANTEO13283, XYL1_CANTR
Q5BGA7, XYL1_EMENIP49378, XYL1_KLULAP78736, XYL1_PACTA
O94735, XYL1_PICGUP31867, XYL1_PICSTQ9P430, XYL1_SCHSH
Q876L8, XYL1_TRIRFP87039, XYL2_CANTR
BRENDA1.1.1.430
MetaCyc1.1.1.430
KEGG Ligand Database for Enzyme Nomenclature1.1.1.430
EC2PDB1.1.1.430
MEDLINEFind literature relating to 1.1.1.430

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