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ENZYME entry: EC 1.1.1.343

Accepted Name
phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating).
Alternative Name(s)
6-PGDH.
Reaction catalysed
6-phospho-D-gluconate + NAD(+) <=> CO2 + D-ribulose 5-phosphate + NADH
Comment(s)
  • Highly specific for NAD(+).
  • The enzyme catalyzes both the oxidation and decarboxylation of 6-phospho-D-gluconate.
  • In the bacterium Methylobacillus flagellatus the enzyme participates in a formaldehyde oxidation pathway.
  • Cf. EC 1.1.1.44.
Cross-references
BRENDA1.1.1.343
EC2PDB1.1.1.343
ExplorEnz1.1.1.343
PRIAM enzyme-specific profiles1.1.1.343
KEGG Ligand Database for Enzyme Nomenclature1.1.1.343
IUBMB Enzyme Nomenclature1.1.1.343
IntEnz1.1.1.343
MEDLINEFind literature relating to 1.1.1.343
MetaCyc1.1.1.343
Rhea expert-curated reactions1.1.1.343
UniProtKB/Swiss-Prot
P12013, 6PGDH_BACSU;  G5EBD7, 6PGDH_GLUOX;  D4GST8, 6PGD_HALVD;  

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