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ENZYME entry: EC 1.1.1.357

Accepted Name
3alpha-hydroxysteroid 3-dehydrogenase.
Alternative Name(s)
3alpha-hydroxysteroid dehydrogenase.
Reaction catalysed
  • a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH
  • a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH
Comment(s)
  • The enzyme acts on multiple 3alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone.
  • The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation.
  • This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
Cross-references
BRENDA1.1.1.357
EC2PDB1.1.1.357
ExplorEnz1.1.1.357
PRIAM enzyme-specific profiles1.1.1.357
KEGG Ligand Database for Enzyme Nomenclature1.1.1.357
IUBMB Enzyme Nomenclature1.1.1.357
IntEnz1.1.1.357
MEDLINEFind literature relating to 1.1.1.357
MetaCyc1.1.1.357
Rhea expert-curated reactions1.1.1.357
UniProtKB/Swiss-Prot
Q04828, AK1C1_HUMAN;  Q95JH7, AK1C1_MACFA;  Q95JH6, AK1C1_MACFU;  
Q5REQ0, AK1C1_PONAB;  P52895, AK1C2_HUMAN;  P42330, AK1C3_HUMAN;  
Q5R7C9, AK1C3_PONAB;  P17516, AK1C4_HUMAN;  Q95JH5, AK1C4_MACFA;  
Q95JH4, AK1C4_MACFU;  

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