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ENZYME

ENZYME entry: EC 1.1.1.357

PURL: https://purl.expasy.org/enzyme/EC/1.1.1.357
Accepted Name
3alpha-hydroxysteroid 3-dehydrogenase
Alternative Name(s)
3alpha-hydroxysteroid dehydrogenase
Reaction catalysed
  • a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH + H(+)
  • a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + NADH + H(+)
Comment(s)
  • The enzyme acts on multiple 3alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone.
  • The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation.
  • This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
Cross-references
BRENDA1.1.1.357
EC2PDB1.1.1.357
ExplorEnz1.1.1.357
KEGG Ligand Database for Enzyme Nomenclature1.1.1.357
IUBMB Enzyme Nomenclature1.1.1.357
MEDLINEFind literature relating to 1.1.1.357
MetaCyc1.1.1.357
Rhea expert-curated reactions1.1.1.357
UniProtKB/Swiss-Prot
Q04828, AK1C1_HUMANQ95JH7, AK1C1_MACFAQ95JH6, AK1C1_MACFU
Q5REQ0, AK1C1_PONABP52895, AK1C2_HUMANP42330, AK1C3_HUMAN
Q5R7C9, AK1C3_PONABP17516, AK1C4_HUMANQ95JH5, AK1C4_MACFA
Q95JH4, AK1C4_MACFU

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