ENZYME entry: EC 1.1.1.357
Accepted Name |
3alpha-hydroxysteroid 3-dehydrogenase.
|
Alternative Name(s) |
3alpha-hydroxysteroid dehydrogenase. |
Reaction catalysed |
- a 3alpha-hydroxysteroid + NADP(+) <=> a 3-oxosteroid + H(+) + NADPH
- a 3alpha-hydroxysteroid + NAD(+) <=> a 3-oxosteroid + H(+) + NADH
|
Comment(s) |
- The enzyme acts on multiple 3alpha-hydroxysteroids, such as
androsterone and 5 alpha-dihydrotestosterone.
- The mammalian enzymes are involved in inactivation of steroid
hormones, while the bacterial enzymes are involved in steroid
degradation.
- This entry stands for enzymes whose stereo-specificity with respect
to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
|
Cross-references |
BRENDA | 1.1.1.357 |
EC2PDB | 1.1.1.357 |
ExplorEnz | 1.1.1.357 |
PRIAM enzyme-specific profiles | 1.1.1.357 |
KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.357 |
IUBMB Enzyme Nomenclature | 1.1.1.357 |
IntEnz | 1.1.1.357 |
MEDLINE | Find literature relating to 1.1.1.357 |
MetaCyc | 1.1.1.357 |
Rhea expert-curated reactions | 1.1.1.357 |
UniProtKB/Swiss-Prot |
Q04828, AK1C1_HUMAN; | Q95JH7, AK1C1_MACFA; | Q95JH6, AK1C1_MACFU; |
Q5REQ0, AK1C1_PONAB; | P52895, AK1C2_HUMAN; | P42330, AK1C3_HUMAN; |
Q5R7C9, AK1C3_PONAB; | P17516, AK1C4_HUMAN; | Q95JH5, AK1C4_MACFA; |
Q95JH4, AK1C4_MACFU; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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